KEGG ENZYME: 3.5.1.111

ENZYME: 3.5.1.111

Entry

EC 3.5.1.111                Enzyme

Name

2-oxoglutaramate amidase;
omega-amidase (ambiguous)

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

5-amino-2,5-dioxopentanoate amidohydrolase

Reaction(IUBMB)

2-oxoglutaramate + H2O = 2-oxoglutarate + NH3 [RN:R00269]

Reaction(KEGG)

R00269

Substrate

2-oxoglutaramate [CPD:C00940];
H2O [CPD:C00001]

Product

2-oxoglutarate [CPD:C00026];
NH3 [CPD:C00014]

Comment

The enzyme, which is highly specific for its substrate, participates in the nicotine degradation pathway of several Gram-positive bacteria.

History

EC 3.5.1.111 created 2012

Pathway

ec00250

Alanine, aspartate and glutamate metabolism

ec01100

Metabolic pathways

Orthology

K08590

2-oxoglutaramate amidase

Genes

PNV:	JMY29_20620

Reference

1 [PMID:21288482]

Authors

Cobzaru C, Ganas P, Mihasan M, Schleberger P, Brandsch R

Title

Homologous gene clusters of nicotine catabolism, including a new omega-amidase for alpha-ketoglutaramate, in species of three genera of Gram-positive bacteria.

Journal

Res Microbiol 162:285-91 (2011)
DOI:10.1016/j.resmic.2011.01.001

Sequence

[ag:CAD47935]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.1.111

IUBMB Enzyme Nomenclature:

3.5.1.111

ExPASy - ENZYME nomenclature database:

3.5.1.111

BRENDA, the Enzyme Database:

3.5.1.111

DBGET integrated database retrieval system