Entry
Name
crotonobetainyl-CoA hydratase;
CaiD;
L-carnityl-CoA dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming]
Reaction(IUBMB)
L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O [RN:
R10675 ]
Reaction(KEGG)
Substrate
Product
(E)-4-(trimethylammonio)but-2-enoyl-CoA [CPD:
C20748 ];
H2O [CPD:
C00001 ]
Comment
The enzyme is also able to use crotonyl-CoA as substrate, with low efficiency [2].
History
EC 4.2.1.149 created 2014
Orthology
K08299 crotonobetainyl-CoA hydratase
Genes
ECOO : ECRM13514_0037(caiD)
ECOH : ECRM13516_0039(caiD)
ECW : EcE24377A_0038(caiD)
EDJ : ECDH1ME8569_0035(caiD)
ECOI : ECOPMV1_00037(caiD_1)
METY : MRY16398_47870(caiD)
PHEI : NCTC12003_00741(caiD)
LRI : NCTC12151_02501(caiD)
SCAA : TUM17387_35790(caiD)
GAI : IMCC3135_12755(caiD)
MRZ : KDW95_01220(caiD) KDW95_01240(caiD)
AMIS : Amn_44470 Amn_pb00780
SMEL : SM2011_c01641(caiD)
SFD : USDA257_c45520(caiD)
SAME : SAMCFNEI73_Ch2523(caiD)
ENU : PYH37_004725 PYH37_006071
REL : REMIM1_PB00143(caiD)
REP : IE4803_PD00564(caiD)
REI : IE4771_PE00579(caiD)
RGA : RGR602_PC01930(caiD)
RPHA : AMC79_PA00228(caiD)
RLW : RlegWSM1455_33810(caiD)
RBW : RLCC275e_32505(caiD)
NEN : NCHU2750_44880(caiD)
SSUM : Q9314_17055 Q9314_27200
OIN : IAR37_19850(caiD) IAR37_19855(caiD)
JAV : OXU80_25065 OXU80_25070
PAQT : E8L99_09250 E8L99_09290
SIL : SPO2706(caiD-1) SPOA0285(caiD-2)
RLI : RLO149_c000760(caiD)
PHP : PhaeoP97_03321(caiD)
PPIC : PhaeoP14_03227(caiD)
SULI : C1J05_06970 C1J05_19880
SINL : DSM14862_02686(caiD)
SPSE : SULPSESMR1_03035(caiD)
RID : RIdsm_00642(caiD_1) RIdsm_04076(caiD_5)
ROM : EI983_04465 EI983_14380
RPEL : N7U68_13775 N7U68_18635
AHT : ANTHELSMS3_00030(caiD)
LALG : LentiSH36_02634(caiD)
LVS : LOKVESSMR4R_02271(caiD)
SEDI : EBB79_11295 EBB79_22480
PSEB : EOK75_06680(caiD) EOK75_14575(caiD)
PAED : G5B38_05425(caiD) G5B38_10250(caiD)
SMAG : AN936_15205 AN936_15975
SMAZ : LH19_02315 LH19_03080
HTQ : FRZ44_11750(caiD) FRZ44_19970(caiD) FRZ44_47680
HADH : FRZ61_11970(caiD) FRZ61_27270(caiD) FRZ61_44380(caiD) FRZ61_45410
BFD : NCTC4823_03672(caiD)
MMAN : MMAN_28130 MMAN_41980
MMAE : MMARE11_41310(echA1_1)
MBAI : MB901379_03773(caiD_4)
MSEO : MSEO_26470 MSEO_30240
MPHL : MPHLCCUG_04147(caiD_3)
MTHN : 4412656_03465(caiD_7)
MDU : MDUV_01330 MDUV_19620 MDUV_30990
MAUU : NCTC10437_04319(caiD_4)
MALV : MALV_21610 MALV_48800
MBOK : MBOE_27610 MBOE_59020
MFLV : NCTC10271_01151(caiD_4)
MMON : EWR22_21015 EWR22_22095
MJD : JDM601_1118(echA1_1)
MTER : 4434518_01077(echA1_1)
NFR : ERS450000_01146(caiD_2)
NAD : NCTC11293_03570(caiD_6)
RCR : NCTC10994_01638(caiD_5)
» show all
Taxonomy
Reference
Authors
Engemann C, Elssner T, Kleber HP
Title
Biotransformation of crotonobetaine to L(-)-carnitine in Proteus sp.
Journal
Sequence
Reference
Authors
Elssner T, Engemann C, Baumgart K, Kleber HP
Title
Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli.
Journal
Sequence
Reference
Authors
Engemann C, Elssner T, Pfeifer S, Krumbholz C, Maier T, Kleber HP
Title
Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.149