KEGG   ENZYME: 6.2.1.15
Entry
EC 6.2.1.15                 Enzyme                                 
Name
arachidonate---CoA ligase;
arachidonoyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
arachidonate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA [RN:R01598]
Reaction(KEGG)
R01598
Substrate
ATP [CPD:C00002];
arachidonate [CPD:C00219];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
arachidonoyl-CoA [CPD:C02249]
Comment
Not identical with EC 6.2.1.3 long-chain-fatty-acid---CoA ligase. Icosa-8,11,14-trienoate, but not the other long-chain fatty acids, can act in place of arachidonate.
History
EC 6.2.1.15 created 1984
Reference
1  [PMID:7061494]
  Authors
Wilson DB, Prescott SM, Majerus PW.
  Title
Discovery of an arachidonoyl coenzyme A synthetase in human platelets.
  Journal
J Biol Chem 257:3510-5 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.15
IUBMB Enzyme Nomenclature: 6.2.1.15
ExPASy - ENZYME nomenclature database: 6.2.1.15
BRENDA, the Enzyme Database: 6.2.1.15
CAS: 82047-87-8

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