Entry
Name
urea carboxylase;
urease (ATP-hydrolysing);
urea carboxylase (hydrolysing);
ATP---urea amidolyase;
urea amidolyase;
UALase;
UCA
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
urea:carbon-dioxide ligase (ADP-forming)
Reaction(IUBMB)
ATP + urea + HCO3- = ADP + phosphate + urea-1-carboxylate [RN:
R00774 ]
Reaction(KEGG)
Substrate
Product
Comment
A biotinyl-protein. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC
3.5.1.54 allophanate hydrolase, thus bringing about the hydrolysis of urea to CO2 and NH3. Previously also listed as EC
3.5.1.45 . The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates [4].
History
EC 6.3.4.6 created 1972, modified 1986 (EC 3.5.1.45 created 1978, incorporated 1986)
Pathway
Orthology
K14541 urea carboxylase / allophanate hydrolase
Genes
NCS : NCAS_0B02280(NCAS0B02280)
NDI : NDAI_0C05400(NDAI0C05400)
TPF : TPHA_0L01560(TPHA0L01560)
TDL : TDEL_0B03290(TDEL0B03290)
KNG : KNAG_0A03800(KNAG0A03800)
CAL : CAALFM_C104660WA(DUR1)
CTEN : CANTEDRAFT_121521 CANTEDRAFT_94782
YLI : YALI0E07271g YALI0E35156g
PKZ : C5L36_0A05680 C5L36_0B06440
BBRX : BRETT_003123(DUR1) BRETT_004561
OPA : HPODL_01823 HPODL_01974
FVR : FVEG_04571 FVEG_11593
FOX : FOXG_07646 FOXG_12848
NHE : NECHADRAFT_44732 NECHADRAFT_79968
FFC : NCS54_00648600 NCS54_00902200
FKR : NCS57_00688700 NCS57_00909300
FMU : J7337_006612 J7337_009998
PCHM : VFPPC_03852 VFPPC_13829
PLJ : VFPFJ_01943 VFPFJ_02005
PTKZ : JDV02_003952 JDV02_004007 JDV02_004980
CFJ : CFIO01_04268 CFIO01_12769
CLUP : CLUP02_01485 CLUP02_03173
CHIG : CH63R_02411 CH63R_10383
PFY : PFICI_00100 PFICI_00808
BSC : COCSADRAFT_193941 COCSADRAFT_91374
NPA : UCRNP2_1608 UCRNP2_84
CCAC : CcaHIS019_0600220(CcaverHIS019_0600220)
ABP : AGABI1DRAFT77573(AGABI1DRAFT_77573)
ABV : AGABI2DRAFT212287(AGABI2DRAFT_212287)
SMIN : v1.2.013193.t1(symbB.v1.2.013193.t1) v1.2.013193.t2(symbB.v1.2.013193.t2)
ENF : AKI40_1885 AKI40_2313
CCON : AFK62_09845 AFK62_19285
CMW : AFK63_08595 AFK63_19335
REE : electrica_02561(accA1)
RTG : NCTC13098_03737(accA1)
CLAP : NCTC11466_02328(accA1)
KOR : AWR26_09495 AWR26_11275(uca) AWR26_16855(uca)
KRD : A3780_07405 A3780_12820 A3780_14485
KOO : O9K67_09300 O9K67_16535(uca)
KIE : NCTC12125_02716(accA1)
KLU : K7B04_10495(uca) K7B04_17505(uca)
AHN : NCTC12129_00122(accC_1) NCTC12129_02476(accC_3) NCTC12129_02477(oadA)
ASUB : NLZ15_00550(uca) NLZ15_11445(uca)
PSGC : G163CM_08880(carB_1) G163CM_17320(carB_2)
PVJ : LMA04_02880(uca) LMA04_16690(uca)
SFJ : SAMEA4384070_1468(accA1)
RBAD : H2866_07525(uca) H2866_07745(uca)
NIG : C1N62_00345(uca) C1N62_20125(uca)
PROD : PCO85_00840(uca) PCO85_08375
SERA : Ser39006_001450(uca) Ser39006_016505
SERQ : CWC46_01450(uca) CWC46_16505
PATR : EV46_09205 EV46_10250
PATO : GZ59_24220 GZ59_26840
PCC : PCC21_022420 PCC21_025000
PWA : Pecwa_2502 Pecwa_2680
PPAR : A8F97_05245 A8F97_06140
PWS : A7983_19840 A7983_20765
PPOA : BJK05_05825 BJK05_06835
PBRA : B5S52_09795 B5S52_10880
PPUJ : E2566_11345(uca) E2566_12425(uca)
PARI : I2D83_11590(uca) I2D83_12810(uca)
PAQU : DMB82_0009655(uca) DMB82_0010220(uca)
PVZ : OA04_18620 OA04_21110(ucaA)
PQU : IG609_010660(uca) IG609_011315(uca)
PPOO : LW347_11135(uca) LW347_12160(uca)
PCAC : OI450_08505(uca) OI450_09215(uca)
PACB : M9782_13250(uca) M9782_14535(uca)
DDD : Dda3937_01002 Dda3937_02462
DZE : Dd1591_0045 Dd1591_2478 Dd1591_2748
DDC : Dd586_0054 Dd586_2424
DZC : W909_00200 W909_07975
DSO : A4U42_09390 A4U42_17920 A4U42_20020
CED : LH89_03485 LH89_11955
DFN : CVE23_00310(uca) CVE23_09355
DIC : Dpoa569_002219 Dpoa569_003847(uca)
BGJ : AWC36_12675 AWC36_19030
BNG : EH206_00355(uca) EH206_16580
LPOP : I6N93_09965 I6N93_14740(uca)
EPE : CI789_08100(uca) CI789_15270(uca)
ERWI : GN242_10500(uca) GN242_17985(uca)
ERP : LJN55_11840(uca) LJN55_19820(uca)
PLF : PANA5342_3669(uca) PANA5342_p10223(uca)
PAQ : PAGR_g3552 PAGR_p152
PVA : Pvag_0052(uaha1) Pvag_pPag30288(uahA)
PAGG : AL522_02055(uca) AL522_07245(uca)
PAO : Pat9b_0101 Pat9b_0598
KLN : LH22_01780 LH22_19210
PAGC : BEE12_10005 BEE12_20320
PANS : FCN45_00510(uca) FCN45_03065(uca)
PEY : EE896_16315(uca) EE896_20920(uca)
PJI : KTJ90_16180(uca) KTJ90_20440(uca)
PANO : OJ965_01385(uca) OJ965_18050(uca)
PALF : K6R05_15910(uca) K6R05_20950(uca)
TCI : A7K98_16530 A7K98_20435
XPH : XppCFBP6546_12175(uca)
VGA : BSQ33_08980 BSQ33_20570
VSR : Vspart_00013(accA1) Vspart_04483(kipI_2)
GKD : K6Q96_19815(uca) K6Q96_24365
PCQ : PcP3B5_39090(accA1_3)
PFV : Psefu_3274 Psefu_4073
PSYR : N018_05605 N018_13650
PSP : PSPPH_2446 PSPPH_3975
PAMG : BKM19_016400 BKM19_023535
PAVL : BKM03_14315 BKM03_23015
PVD : CFBP1590__1311(DUR1) CFBP1590__2827
PFN : HZ99_10065 HZ99_24875
PVR : PverR02_07365 PverR02_24400
PMUD : NCTC8068_03984(kipI_2)
PTOL : I7845_07125(uca) I7845_22420
PSK : U771_08315 U771_24935
PSES : PSCI_4417 PSCI_4770 PSCI_5509
PANR : A7J50_1570 A7J50_4561
PPSL : BJP27_01990 BJP27_07115
PYM : AK972_1249 AK972_4543
PUM : HGP31_07195(uca) HGP31_19825
POJ : PtoMrB4_05240 PtoMrB4_22130
PSEJ : HNQ25_17690(uca) HNQ25_20760(uca)
PTY : JWV26_14420(uca) JWV26_17425
PTAE : NCTC10697_02265(kipI_1)
PHF : NLY38_03540(uca) NLY38_18360(uca)
PCHE : QYM18_11280(uca) QYM18_14495(uca)
PPHA : BVH74_07875 BVH74_08240
MSQ : BKP64_05810 BKP64_17915
MARA : D0851_07780 D0851_07785 D0851_09810(uca)
MALL : PBN92_15105(uca) PBN92_17070(uca)
ABB : ABBFA_02220(accA1_3)
AJO : RZ95_03725 RZ95_08970
AHL : AHTJS_08070 AHTJS_08185
AJN : BVL33_09890 BVL33_10065
ACUM : C9E88_006635(uca) C9E88_012445(uca)
ALW : FOB21_01840(uca) FOB21_14715(uca)
AGYL : FPL18_16870(uca) FPL18_18395(uca)
AVZ : HWI77_08390(uca) HWI77_09450(uca)
ACOI : NQU59_13235(uca) NQU59_14420(uca)
CEB : B0D95_00670 B0D95_10495
CELL : CBR65_18200 CBR65_19900
CEK : D0B88_07885(uca) D0B88_08825(uca)
CEG : D0C16_11380(uca) D0C16_22005(uca)
MKE : OOT55_10280(uca) OOT55_17465(uca)
THIO : AYJ59_03330 AYJ59_04300
HNA : Hneap_0798 Hneap_1105
HAZ : A9404_00120 A9404_08250
HAA : A5892_06700 A5892_09555 A5892_15570 A5892_18615
ALCA : ASALC70_01824(accA1_1) ASALC70_03441(accA1_2)
ADI : B5T_00740 B5T_01163(uahA)
APAC : S7S_02705 S7S_12175
FCE : JN531_004965(uca) JN531_005950(uca)
BVI : Bcep1808_3856 Bcep1808_5578
BVE : AK36_4856 AK36_5070(uca)
BCM : Bcenmc03_2954 Bcenmc03_6430
BCEN : DM39_3027 DM39_3454(uca)
BCED : DM42_2132 DM42_6767(uca)
BCEP : APZ15_02575 APZ15_35555
BPSL : WS57_06390 WS57_33460
BSTL : BBJ41_13955 BBJ41_37545
BGD : bgla_1g26960 bgla_2g25600
BGO : BM43_148 BM43_6293(uca)
BURK : DM992_33520(uca) DM992_41370
PSPW : BJG93_15790(uca) BJG93_33415(uca)
PMEG : FNZ07_06610(uca) FNZ07_17095
PTRO : G5S35_26070 G5S35_32705
PKF : RW095_08335 RW095_12915(uca) RW095_19745
PPAI : E1956_30730 E1956_36810(uca)
PLG : NCTC10937_01303(accA1_1)
BHZ : ACR54_01301(accA1_1)
BTRM : SAMEA390648701057(kipI_2)
AXY : AXYL_04917 AXYL_05232(uca)
AXO : NH44784_019861 NH44784_033381
AXN : AX27061_0216 AX27061_5021
AXX : ERS451415_00215(kipI_1) ERS451415_05058(accA1_3)
ADT : APT56_01325 APT56_23070
ACHR : C2U31_04710 C2U31_28910(uca)
APES : FOC84_19880(uca) FOC84_21415
AAEG : RA224_06500(uca) RA224_07815
PVAC : HC248_02604(accA1_2)
HSE : Hsero_4114 Hsero_4471
HSZ : ACP92_20535 ACP92_22325
HRB : Hrubri_4045 Hrubri_4414
HHF : E2K99_21305 E2K99_23525(uca)
SPLB : SFPGR_15760 SFPGR_15850
RBS : RHODOSMS8_03364(accA1)
ARUI : G6M88_20915 G6M88_23535
AVV : RvVAT039_00070 RvVAT039_41740
AVF : RvVAR031_21310 RvVAR031_34230
ALEG : CFBP4996_01355(uca)
AVI : Avi_2502(pccA) Avi_5869
RTR : RTCIAT899_PC07770(uca)
RHR : CKA34_24800 CKA34_26530(uca)
RII : FFM53_028290 FFM53_033720(uca)
RLS : HB780_03650 HB780_11910(uca)
RLW : RlegWSM1455_25010 RlegWSM1455_32800(uca)
RRHO : PR018_06850 PR018_24705(uca)
RTU : PR017_06965 PR017_25540(uca)
ARA : Arad_10038(uca) Arad_7499
BEL : BE61_65950 BE61_85370(pccA)
BQB : J4P68_0012785(uca) J4P68_0028130
BAUT : QA635_26410 QA635_36830(uca)
BBRA : QA636_28205 QA636_37960(uca)
MAQU : Maq22A_2p41220(dur1)
AUZ : Sa4125_19420 Sa4125_46750
PPHR : APZ00_02415 APZ00_23765
ROM : EI983_01785 EI983_15375
LVS : LOKVESSMR4R_03019(accA1)
AZL : AZL_a02430 AZL_b03890
NCB : C0V82_20990(uca) C0V82_24160(uca)
MGRY : MSR1_01220(accA1_1)
HTQ : FRZ44_06530 FRZ44_19050
BFD : NCTC4823_03365(kipI_2) NCTC4823_03417(kipI_3) NCTC4823_03431(kipI_4)
BBAD : K7T73_17995 K7T73_19345 K7T73_19415
BDA : FSZ17_20100 FSZ17_20165
HMN : HM131_01990 HM131_05225
PBUT : DTO10_16080 DTO10_16110
SFOR : QNH23_12440 QNH23_12735 QNH23_12805
BCHS : JNE38_20475 JNE38_20505
BBOR : RFB14_13760 RFB14_13785
ANX : ACH33_08785 ACH33_08815
ATHE : K3F53_10275 K3F53_10305
CEW : EKH84_04090 EKH84_05370(uca)
MTHN : 4412656_02193(accA1_1)
MHAS : MHAS_01265(accA1_3)
MARZ : MARA_20170 MARA_35860
MSAL : DSM43276_03931(kipA_1)
CGY : CGLY_10555 CGLY_10940
CPRE : Csp1_19630(accA1_3) Csp1_26490(kipI)
NFR : ERS450000_00322(kipI_1) ERS450000_01878(kipI_3)
NSL : BOX37_01445 BOX37_28780
NSR : NS506_01456 NS506_03809
NGP : LTT66_14380(uca) LTT66_17075
NSPU : IFM12276_04980 IFM12276_67410
RHA : RHA1_ro02135 RHA1_ro06922
ROA : Pd630_LPD03538 Pd630_LPD06315
RAV : AAT18_12655 AAT18_19825
RRZ : CS378_02380 CS378_09310(uca)
RHU : A3Q40_01989(accA1_3) A3Q40_02481(kipA_1)
RRT : 4535765_01457 4535765_03780(accA1_3)
RCR : NCTC10994_01344 NCTC10994_03486(accA1_2)
RTM : G4H71_14995(uca) G4H71_20755
RKO : JWS14_11170(uca) JWS14_37235
ROZ : CBI38_07465 CBI38_16755
RPSK : JWS13_06960 JWS13_34700(uca)
GJI : H1R19_05050 H1R19_18455
TSM : ASU32_04290 ASU32_08590
SCI : B446_01065 B446_34230
SGE : DWG14_06847(accA1_3)
ARU : ASPU41_03590 ASPU41_03615
AAGI : NCTC2676_1_01188(accC_2)
PSNI : NIBR502771_03900(uca)
CELH : GXP71_14845(uca) GXP71_19665(uca)
SACG : FDZ84_26375 FDZ84_27445
AMYC : CU254_12360 CU254_12420
AMYB : BKN51_05735 BKN51_09155
AACD : LWP59_10375 LWP59_19615
PBRO : HOP40_29355 HOP40_29415 HOP40_31530
PPEL : H6H00_07140 H6H00_29570
SBAE : DSM104329_02345 DSM104329_02357(pxpB)
» show all
Taxonomy
Reference
1
Authors
Roon, R.J. and Levenberg, B.
Title
ATP-Urea amidolyase (ADP) (Candida utilis).
Journal
Methods Enzymol 17A:317-324 (1970)
Reference
Authors
Roon RJ, Levenberg B.
Title
Urea amidolyase. I. Properties of the enzyme from Candida utilis.
Journal
J Biol Chem 247:4107-13 (1972)
Reference
Authors
Sumrada RA, Cooper TG.
Title
Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast.
Journal
J Biol Chem 257:9119-27 (1982)
Reference
Authors
Kanamori T, Kanou N, Atomi H, Imanaka T
Title
Enzymatic characterization of a prokaryotic urea carboxylase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.6
ExPASy - ENZYME nomenclature database: 6.3.4.6
BRENDA, the Enzyme Database: 6.3.4.6