Description
NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import [Source:SGD;Acc:S000002180]
Gene Synonyms
DAR1, HOR1, OSG1, OSR5
Location
Chromosome IV: 411,825-413,000 forward strand.
R64-1-1:BK006938.2
About this gene
This gene has 1 transcript (splice variant), 582 orthologues and 1 paralogue.
Transcripts
