AmiGO 2: Term Details for "cytochrome-c oxidase activity" (GO:0004129)

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Term Information

Accession: GO:0004129
Name: cytochrome-c oxidase activity
Ontology: molecular_function
Synonyms: cytochrome c oxidase activity, Warburg's respiratory enzyme activity, complex IV (mitochondrial electron transport) activity, cytochrome oxidase activity, aa3-type cytochrome c oxidase, ba3-type cytochrome c oxidase, caa3-type cytochrome c oxidase, cbb3-type cytochrome c oxidase, cytochrome a3 activity, cytochrome aa3 activity, indophenol oxidase, indophenolase
Alternate IDs: None
Definition: Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. Source: RHEA:11436
Comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
History: See term history for GO:0004129 at QuickGO
Chem. react.: has participant iron(3+); has participant iron(2+); has participant hydron; has participant dioxygen; has participant water
Subset: None
Related: Link to all genes and gene products annotated to cytochrome-c oxidase activity (excluding "regulates").; Link to all direct and indirect annotations to cytochrome-c oxidase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for cytochrome-c oxidase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0051179 localization
GO:0051234 establishment of localization
GO:0009987 cellular process
GO:0003674 molecular_function
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0006810 transport
GO:0098660 inorganic ion transmembrane transport
GO:0006812 monoatomic cation transport
GO:0034220 monoatomic ion transmembrane transport
GO:0022857 transmembrane transporter activity
GO:0005215 transporter activity
GO:0022804 active transmembrane transporter activity
GO:0003824 catalytic activity
GO:0098662 inorganic cation transmembrane transport
GO:0015318 inorganic molecular entity transmembrane transporter activity
GO:0098655 monoatomic cation transmembrane transport
GO:0015075 monoatomic ion transmembrane transporter activity
GO:0022890 inorganic cation transmembrane transporter activity
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0016491 oxidoreductase activity
GO:0015399 primary active transmembrane transporter activity
GO:1902600 proton transmembrane transport
GO:0022853 active monoatomic ion transmembrane transporter activity
GO:0009055 electron transfer activity
GO:0016675 oxidoreductase activity, acting on a heme group of donors
GO:0015453 oxidoreduction-driven active transmembrane transporter activity
GO:0015078 proton transmembrane transporter activity
GO:0004129 cytochrome-c oxidase activity
GO:1905376 negative regulation of cytochrome-c oxidase activity
GO:1904960 positive regulation of cytochrome-c oxidase activity
GO:1904959 regulation of cytochrome-c oxidase activity

Parents of cytochrome-c oxidase activity (GO:0004129)

subject	relation	object
cytochrome-c oxidase activity	RO:0000057	iron(3+) (CHEBI:29034)
cytochrome-c oxidase activity	is_a	oxidoreduction-driven active transmembrane transporter activity (GO:0015453)
cytochrome-c oxidase activity	is_a	oxidoreductase activity, acting on a heme group of donors (GO:0016675)
cytochrome-c oxidase activity	RO:0000057	iron(2+) (CHEBI:29033)
cytochrome-c oxidase activity	RO:0000057	hydron (CHEBI:15378)
cytochrome-c oxidase activity	is_a	active monoatomic ion transmembrane transporter activity (GO:0022853)
cytochrome-c oxidase activity	is_a	electron transfer activity (GO:0009055)
cytochrome-c oxidase activity	RO:0000057	dioxygen (CHEBI:15379)
cytochrome-c oxidase activity	is_a	proton transmembrane transporter activity (GO:0015078)
cytochrome-c oxidase activity	RO:0000057	water (CHEBI:15377)

Children of cytochrome-c oxidase activity (GO:0004129)

subject	relation	object
positive regulation of cytochrome-c oxidase activity (GO:1904960)	RO:0002213	cytochrome-c oxidase activity
regulation of cytochrome-c oxidase activity (GO:1904959)	RO:0002211	cytochrome-c oxidase activity
negative regulation of cytochrome-c oxidase activity (GO:1905376)	RO:0002212	cytochrome-c oxidase activity

EC: 7.1.1.9
MetaCyc: CYTOCHROME-C-OXIDASE-RXN
Reactome: R-HSA-163214
RHEA: 11436