AmiGO 2: Term Details for "MAP kinase activity" (GO:0004707)

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Term Information

Accession: GO:0004707
Name: MAP kinase activity
Ontology: molecular_function
Synonyms: ERK1, mitogen activated kinase activity, ATP:protein phosphotransferase (MAPKK-activated) activity, ERK, ERK2, MAPK, mitogen-activated protein kinase activity, MAP kinase 1 activity, MAP kinase 2 activity, MBP kinase I activity, MBP kinase II activity, SAP kinase activity, SAPK, extracellular signal-regulated kinase activity, myelin basic protein kinase activity, stress-activated kinase activity, stress-activated protein kinase activity
Alternate IDs: GO:0008338, GO:0008339, GO:0016908, GO:0016909
Definition: Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. Source: ISBN:0198547684, GOC:ma
Comment: None
History: See term history for GO:0004707 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to MAP kinase activity (excluding "regulates").; Link to all direct and indirect annotations to MAP kinase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for MAP kinase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0003824 catalytic activity
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical structure
GO:0051716 cellular response to stimulus
GO:0003674 molecular_function
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0016740 transferase activity
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0140096 catalytic activity, acting on a protein
GO:0035556 intracellular signal transduction
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0141124 intracellular signaling cassette
GO:0004672 protein kinase activity
GO:0000165 MAPK cascade
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004705 JUN kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043405 regulation of MAP kinase activity

Parents of MAP kinase activity (GO:0004707)

subject	relation	object
MAP kinase activity	BFO:0000050	MAPK cascade (GO:0000165)
MAP kinase activity	is_a	protein serine/threonine kinase activity (GO:0004674)
MAP kinase activity	RO:0002162	Eukaryota (NCBITaxon:2759)

Children of MAP kinase activity (GO:0004707)

subject	relation	object
JUN kinase activity (GO:0004705)	is_a	MAP kinase activity
regulation of MAP kinase activity (GO:0043405)	RO:0002211	MAP kinase activity
positive regulation of MAP kinase activity (GO:0043406)	RO:0002213	MAP kinase activity
negative regulation of MAP kinase activity (GO:0043407)	RO:0002212	MAP kinase activity

EC: 2.7.11.24
KEGG_REACTION: R00162
MetaCyc: 2.7.11.24-RXN
Reactome: R-HSA-445079; R-HSA-9626832; R-HSA-9825759; R-HSA-73722; R-HSA-5654560; R-HSA-198733; R-HSA-111898; R-HSA-5654562; R-HSA-5654566; R-HSA-5654565