AmiGO 2: Term Details for "MAP kinase kinase kinase activity" (GO:0004709)

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Term Information

Accession: GO:0004709
Name: MAP kinase kinase kinase activity
Ontology: molecular_function
Synonyms: MAPK/ERK kinase kinase activity, MEKK activity, ATP:protein phosphotransferase (MAPKKKK-activated) activity, MAP3K, MAPKKK activity, MEK kinase activity, MEKK, MEKK1, MEKK2, MEKK3, MLTK, MLTKa, MLTKb, Mil/Raf, REKS, STK28, cMos, cRaf, mitogen-activated protein kinase kinase kinase activity, MLK-like mitogen-activated protein triple kinase activity
Alternate IDs: GO:0004710
Definition: Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. Source: PMID:9561267
Comment: None
History: See term history for GO:0004709 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to MAP kinase kinase kinase activity (excluding "regulates").; Link to all direct and indirect annotations to MAP kinase kinase kinase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for MAP kinase kinase kinase activity (excluding "regulates").

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0003824 catalytic activity
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical structure
GO:0051716 cellular response to stimulus
GO:0003674 molecular_function
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0016740 transferase activity
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0140096 catalytic activity, acting on a protein
GO:0035556 intracellular signal transduction
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0141124 intracellular signaling cassette
GO:0004672 protein kinase activity
GO:0000165 MAPK cascade
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004706 JUN kinase kinase kinase activity

Parents of MAP kinase kinase kinase activity (GO:0004709)

subject	relation	object
MAP kinase kinase kinase activity	is_a	protein serine/threonine kinase activity (GO:0004674)
MAP kinase kinase kinase activity	RO:0002162	Eukaryota (NCBITaxon:2759)
MAP kinase kinase kinase activity	BFO:0000050	MAPK cascade (GO:0000165)

Children of MAP kinase kinase kinase activity (GO:0004709)

subject	relation	object
JUN kinase kinase kinase activity (GO:0004706)	is_a	MAP kinase kinase kinase activity

EC: 2.7.11.25
MetaCyc: 2.7.11.25-RXN
Reactome: R-HSA-392530; R-HSA-933530; R-HSA-451649; R-HSA-2730887; R-HSA-727819