AmiGO 2: Term Details for "cysteine-type deubiquitinase activity" (GO:0004843)

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Term Information

Accession: GO:0004843
Name: cysteine-type deubiquitinase activity
Ontology: molecular_function
Synonyms: thiol-dependent deubiquitinase, thiol-dependent ubiquitin-specific protease activity, thiol-dependent ubiquitinyl hydrolase activity, ubiquitin C-terminal hydrolase, UBP, UCH2, ubiquitinyl hydrolase 1 activity, deubiquitinase, deubiquitinase activity, deubiquitinating enzyme, deubiquitylase, ubiquitin hydrolase activity, ubiquitin-specific protease activity, ubiquitinyl hydrolase activity
Alternate IDs: GO:0036459
Definition: An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. Source: PMID:30783221, GOC:jh2
Comment: None
History: See term history for GO:0004843 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to cysteine-type deubiquitinase activity (excluding "regulates").; Link to all direct and indirect annotations to cysteine-type deubiquitinase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for cysteine-type deubiquitinase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0140096 catalytic activity, acting on a protein
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0019783 ubiquitin-like protein peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0101005 deubiquitinase activity
GO:0004843 cysteine-type deubiquitinase activity
GO:0061815 Met1-linked polyubiquitin deubiquitinase activity
GO:2000157 negative regulation of ubiquitin-specific protease activity
GO:2000158 positive regulation of ubiquitin-specific protease activity
GO:2000152 regulation of ubiquitin-specific protease activity
GO:0000124 SAGA complex
GO:1990861 Ubp3-Bre5 deubiquitination complex

Parents of cysteine-type deubiquitinase activity (GO:0004843)

subject	relation	object
cysteine-type deubiquitinase activity	is_a	cysteine-type peptidase activity (GO:0008234)
cysteine-type deubiquitinase activity	is_a	deubiquitinase activity (GO:0101005)

Children of cysteine-type deubiquitinase activity (GO:0004843)

subject	relation	object
negative regulation of ubiquitin-specific protease activity (GO:2000157)	RO:0002212	cysteine-type deubiquitinase activity
SAGA complex (GO:0000124)	RO:0002215	cysteine-type deubiquitinase activity
regulation of ubiquitin-specific protease activity (GO:2000152)	RO:0002211	cysteine-type deubiquitinase activity
Met1-linked polyubiquitin deubiquitinase activity (GO:0061815)	is_a	cysteine-type deubiquitinase activity
Ubp3-Bre5 deubiquitination complex (GO:1990861)	RO:0002215	cysteine-type deubiquitinase activity
positive regulation of ubiquitin-specific protease activity (GO:2000158)	RO:0002213	cysteine-type deubiquitinase activity
protein deubiquitination (GO:0016579)	BFO:0000051	cysteine-type deubiquitinase activity

EC: 3.4.19.12
Reactome: R-HSA-5696947; R-HSA-4641236; R-HSA-8853515; R-HSA-8853514; R-HSA-5696627; R-HSA-9653514; R-HSA-5696945; R-HSA-6807206; R-HSA-5655466; R-HSA-5691381; R-HSA-5696872; R-HSA-6783177; R-HSA-2179291; R-HSA-8865182; R-HSA-8873946; R-HSA-6781779; R-HSA-6781814; R-HSA-6782628; R-HSA-5690759; R-HSA-5690319; R-HSA-5690790; R-HSA-5690152; R-HSA-5690196; R-HSA-5696534; R-HSA-6782069; R-HSA-6782820; R-HSA-5688837; R-HSA-5690157; R-HSA-8853503; R-HSA-5690159; R-HSA-6782106; R-HSA-6781897; R-HSA-870437; R-HSA-6807118; R-HSA-1358795; R-HSA-8862184; R-HSA-5690080; R-HSA-5689973; R-HSA-5689972; R-HSA-8869456; R-HSA-5696465; R-HSA-9033491; R-HSA-3215295; R-HSA-9033478; R-HSA-5696600; R-HSA-6781764; R-HSA-5696968; R-HSA-5696605; R-HSA-8875443; R-HSA-5688797; R-HSA-3640872; R-HSA-8986083; R-HSA-5696914; R-HSA-8853529; R-HSA-5696958; R-HSA-5696997; R-HSA-5697009; R-HSA-3215310; R-HSA-5653770; R-HSA-5689950; R-HSA-5696564; R-HSA-5696960; R-HSA-6786171