AmiGO 2: Term Details for "anaphase-promoting complex" (GO:0005680)

Accession: GO:0005680
Name: anaphase-promoting complex
Ontology: cellular_component
Synonyms: anaphase promoting complex, cyclosome, APC
Alternate IDs: None
Definition: A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. Source: GOC:jh, GOC:vw, PMID:10465783, PMID:10611969
Comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
History: See term history for GO:0005680 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to anaphase-promoting complex (excluding "regulates").; Link to all direct and indirect annotations to anaphase-promoting complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for anaphase-promoting complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
anaphase-promoting complex	is_a	nuclear ubiquitin ligase complex (GO:0000152)
anaphase-promoting complex	is_a	cullin-RING ubiquitin ligase complex (GO:0031461)

This term has no children.