AmiGO 2: Term Details for "cell surface receptor signaling pathway via JAK-STAT" (GO:0007259)

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Term Information

Accession: GO:0007259
Name: cell surface receptor signaling pathway via JAK-STAT
Ontology: biological_process
Synonyms: JAK-STAT signal transduction, receptor signaling pathway via JAK-STAT, JAK-STAT cascade
Alternate IDs: None
Definition: A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. Source: PMID:12039028
Comment: None
History: See term history for GO:0007259 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to cell surface receptor signaling pathway via JAK-STAT (excluding "regulates").; Link to all direct and indirect annotations to cell surface receptor signaling pathway via JAK-STAT (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for cell surface receptor signaling pathway via JAK-STAT (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0097696 cell surface receptor signaling pathway via STAT
GO:0007259 cell surface receptor signaling pathway via JAK-STAT
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0007260 tyrosine phosphorylation of STAT protein

Parents of cell surface receptor signaling pathway via JAK-STAT (GO:0007259)

subject	relation	object
cell surface receptor signaling pathway via JAK-STAT	is_a	cell surface receptor signaling pathway via STAT (GO:0097696)

Children of cell surface receptor signaling pathway via JAK-STAT (GO:0007259)

subject	relation	object
tyrosine phosphorylation of STAT protein (GO:0007260)	BFO:0000050	cell surface receptor signaling pathway via JAK-STAT
negative regulation of receptor signaling pathway via JAK-STAT (GO:0046426)	RO:0002212	cell surface receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via JAK-STAT (GO:0046425)	RO:0002211	cell surface receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via JAK-STAT (GO:0046427)	RO:0002213	cell surface receptor signaling pathway via JAK-STAT
symbiont-mediated suppression of host JAK-STAT cascade (GO:0039514)	RO:0012014	cell surface receptor signaling pathway via JAK-STAT

Wikipedia: JAK-STAT_signaling_pathway