AmiGO 2: Term Details for "death-inducing signaling complex" (GO:0031264)

Term Information

Accession: GO:0031264
Name: death-inducing signaling complex
Ontology: cellular_component
Synonyms: DISC, DISC protein complex, death receptor-induced signaling complex, death receptor-induced signalling complex, death-inducing signalling complex
Alternate IDs: None
Definition: A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. Source: PMID:12628743, PMID:8521815, GOC:mtg_apoptosis, PMID:12655293
Comment: Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10.
History: See term history for GO:0031264 at QuickGO
Chem. react.: None
Subset: goslim_pir
Related: Link to all genes and gene products annotated to death-inducing signaling complex (excluding "regulates").; Link to all direct and indirect annotations to death-inducing signaling complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for death-inducing signaling complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0005575 cellular_component
GO:0110165 cellular anatomical entity
PR:000050567 protein-containing material entity
GO:0071944 cell periphery
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0098796 membrane protein complex
GO:0005886 plasma membrane
GO:0098797 plasma membrane protein complex
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0031266 TRAIL death-inducing signaling complex

Parents of death-inducing signaling complex (GO:0031264)

subject	relation	object
death-inducing signaling complex	is_a	plasma membrane protein complex (GO:0098797)

Children of death-inducing signaling complex (GO:0031264)

subject	relation	object
death-inducing signaling complex assembly (GO:0071550)	RO:0002588	death-inducing signaling complex
TRAIL death-inducing signaling complex (GO:0031266)	is_a	death-inducing signaling complex
CD95 death-inducing signaling complex (GO:0031265)	is_a	death-inducing signaling complex

Wikipedia: Death-inducing_signaling_complex