AmiGO 2: Term Details for "4-amino-4-deoxychorismate synthase activity" (GO:0046820)

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Term Information

Accession: GO:0046820
Name: 4-amino-4-deoxychorismate synthase activity
Ontology: molecular_function
Synonyms: ADC synthase activity, PabB activity, aminodeoxychorismate synthase activity, chorismate:L-glutamine amido-ligase activity, p-aminobenzoate synthetase, para-aminobenzoic acid (PABA) synthase, para-aminobenzoic acid synthase activity
Alternate IDs: None
Definition: Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. Source: EC:2.6.1.85, RHEA:11672
Comment: Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
History: See term history for GO:0046820 at QuickGO
Chem. react.: has participant L-glutamate(1-); has participant chorismate(2-); has participant L-glutamine zwitterion; has participant 4-amino-4-deoxychorismate(1-)
Subset: None
Related: Link to all genes and gene products annotated to 4-amino-4-deoxychorismate synthase activity (excluding "regulates").; Link to all direct and indirect annotations to 4-amino-4-deoxychorismate synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for 4-amino-4-deoxychorismate synthase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016769 transferase activity, transferring nitrogenous groups
GO:0008483 transaminase activity
GO:0046820 4-amino-4-deoxychorismate synthase activity

Parents of 4-amino-4-deoxychorismate synthase activity (GO:0046820)

subject	relation	object
4-amino-4-deoxychorismate synthase activity	is_a	transaminase activity (GO:0008483)
4-amino-4-deoxychorismate synthase activity	RO:0000057	L-glutamate(1-) (CHEBI:29985)
4-amino-4-deoxychorismate synthase activity	RO:0000057	chorismate(2-) (CHEBI:29748)
4-amino-4-deoxychorismate synthase activity	RO:0000057	L-glutamine zwitterion (CHEBI:58359)
4-amino-4-deoxychorismate synthase activity	RO:0000057	4-amino-4-deoxychorismate(1-) (CHEBI:58406)

This term has no children.

EC: 2.6.1.85
KEGG_REACTION: R01716
MetaCyc: PABASYN-RXN
RHEA: 11672