Term Information

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Accession
GO:0061684
Name
chaperone-mediated autophagy
Ontology
biological_process
Synonyms
chaperone-assisted selective autophagy, CASA, CMA
Alternate IDs
None
Definition
The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded. Source: GOC:PARL, PMID:22743996, GOC:pad, PMID:23434281
Comment
None
History
See term history for GO:0061684 at QuickGO
Chem. react.
has participant lysosome
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0061684 from QuickGO

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Parents of chaperone-mediated autophagy (GO:0061684)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
chaperone-mediated autophagy [is_a relation] is_a  protein catabolic process (GO:0030163)
chaperone-mediated autophagy [is_a relation] is_a  autophagy (GO:0006914)
chaperone-mediated autophagy [RO:0002224 relation] RO:0002224  protein-folding chaperone binding (GO:0051087)
chaperone-mediated autophagy [RO:0000057 relation] RO:0000057  lysosome (GO:0005764)
chaperone-mediated autophagy [BFO:0000051 relation] BFO:0000051  protein carrier chaperone (GO:0140597)
chaperone-mediated autophagy [RO:0004009 relation] RO:0004009  protein (PR:000000001)
chaperone-mediated autophagy [BFO:0000051 relation] BFO:0000051  signaling receptor binding (GO:0005102)
Children of chaperone-mediated autophagy (GO:0061684)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of chaperone-mediated autophagy (GO:1904714) [RO:0002211 relation] RO:0002211  chaperone-mediated autophagy
positive regulation of chaperone-mediated autophagy (GO:1904716) [RO:0002213 relation] RO:0002213  chaperone-mediated autophagy
negative regulation of chaperone-mediated autophagy (GO:1904715) [RO:0002212 relation] RO:0002212  chaperone-mediated autophagy
protein targeting to lysosome involved in chaperone-mediated autophagy (GO:0061740) [BFO:0000050 relation] BFO:0000050  chaperone-mediated autophagy
chaperone-mediated autophagy translocation complex assembly (GO:1904763) [BFO:0000050 relation] BFO:0000050  chaperone-mediated autophagy