AmiGO 2: Term Details for "ERK1 and ERK2 cascade" (GO:0070371)

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Term Information

Accession: GO:0070371
Name: ERK1 and ERK2 cascade
Ontology: biological_process
Synonyms: ERK1 and ERK2 signaling pathway, ERK1 and ERK2 signalling pathway, ERK1/2 cascade, extracellular signal-regulated kinase 1/2 (ERK1/2) cascade, extracellular signal-regulated kinase 1/2 cascade, ERK1 cascade, ERK2 cascade, MAPK1 cascade, MAPK3 cascade, ERK cascade
Alternate IDs: None
Definition: A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development. Source: PMID:20811974, PMID:28903453, PMID:23125017
Comment: Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2 and should not be confused with cascades that involve other ERK kinases.
History: See term history for GO:0070371 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to ERK1 and ERK2 cascade (excluding "regulates").; Link to all direct and indirect annotations to ERK1 and ERK2 cascade (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for ERK1 and ERK2 cascade (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0000165 MAPK cascade
GO:0070371 ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade

Parents of ERK1 and ERK2 cascade (GO:0070371)

subject	relation	object
ERK1 and ERK2 cascade	is_a	MAPK cascade (GO:0000165)

Children of ERK1 and ERK2 cascade (GO:0070371)

subject	relation	object
negative regulation of ERK1 and ERK2 cascade (GO:0070373)	RO:0002212	ERK1 and ERK2 cascade
regulation of ERK1 and ERK2 cascade (GO:0070372)	RO:0002211	ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	RO:0002213	ERK1 and ERK2 cascade

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