AmiGO 2: Term Details for "diphthine methyl ester synthase activity" (GO:0141133)

Accession: GO:0141133
Name: diphthine methyl ester synthase activity
Ontology: molecular_function
Synonyms: None
Alternate IDs: None
Definition: Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H+ + 4 S-adenosyl-L-homocysteine. Source: RHEA:42652, PMID:24739148
Comment: This activity is present in eukaryotes and is part of the biosynthetic pathway of diphthamide. Note that this is different from the archaeal enzyme, diphthine synthase activity ; GO:0004164 (EC:2.1.1.98), which performs only 3 methylations, producing diphthine.
History: See term history for GO:0141133 at QuickGO
Chem. react.: has participant hydron; has participant diphthine methyl ester residue; has participant 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine zwitterion residue; has participant S-adenosyl-L-methionine zwitterion; has participant S-adenosyl-L-homocysteine zwitterion
Subset: None
Related: Link to all genes and gene products annotated to diphthine methyl ester synthase activity (excluding "regulates").; Link to all direct and indirect annotations to diphthine methyl ester synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for diphthine methyl ester synthase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
diphthine methyl ester synthase activity	RO:0000057	hydron (CHEBI:15378)
diphthine methyl ester synthase activity	is_a	S-adenosylmethionine-dependent methyltransferase activity (GO:0008757)
diphthine methyl ester synthase activity	RO:0000057	diphthine methyl ester residue (CHEBI:79005)
diphthine methyl ester synthase activity	RO:0000057	2-[(3S)-3-amino-3-carboxypropyl]-L-histidine zwitterion residue (CHEBI:73995)
diphthine methyl ester synthase activity	RO:0000057	S-adenosyl-L-methionine zwitterion (CHEBI:59789)
diphthine methyl ester synthase activity	RO:0002160	Eukaryota (NCBITaxon:2759)
diphthine methyl ester synthase activity	RO:0000057	S-adenosyl-L-homocysteine zwitterion (CHEBI:57856)
diphthine methyl ester synthase activity	is_a	protein methyltransferase activity (GO:0008276)

This term has no children.