HAMAP rule MF_01400
General rule information
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| Accession | MF_01400 |
| Dates | 8-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 33) |
| Name | MsrB |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P14930 (MSRAB_NEIGO); Q9JWM8 (MSRAB_NEIMA); P0A746 (MSRB_ECOLI); Q3JRF0 (MSRB_BURP1); P0A088 (MSRB_STAA8); [ Recover all ] |
| Triggered by |
HAMAP; MF_01400 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MSRB |
| Protein name | RecName: Full=Peptide methionine sulfoxide reductase MsrB; EC=1.8.4.12; AltName: Full=Peptide-methionine (R)-S-oxide reductase; |
| Gene name | Name=msrB; |
Comments
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| CATALYTIC ACTIVITY | Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]; Xref=Rhea:RHEA:24164, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12314, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:45764, ChEBI:CHEBI:50058; EC=1.8.4.12; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.; |
| end case | |
| SIMILARITY | Belongs to the MsrB Met sulfoxide reductase family. |
Keywords
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| Oxidoreductase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0033743; Molecular function:peptide-methionine (R)-S-oxide reductase activity | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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Features
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| From: MSRB_ECOLI (P0A746) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 118 | 118 | /note="Nucleophile" | C | ||||||||
| BINDING | 46 | 46 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 49 | 49 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 95 | 95 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 98 | 98 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 124-159 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_01401 (msrA) Cter: MF_01401 (msrA) |