KEGG DISEASE: Poor drug metabolism

KEGG

DISEASE: Poor drug metabolism

Entry

H01171                      Disease

Name

Poor drug metabolism

Description

Many administered drugs are first activated by phase I drug-metabolizing enzymes, such as cytochrome P450 (CYP). There are some defective activity mutants due to CYP polymorphisms. In these cases, drugs are not metabolized, the high drug levels in blood are maintained, and toxic effects appear in the patients.

Category

Inherited metabolic disorder

Pathway

Drug metabolism - cytochrome P450

Gene

CYP2C19 [HSA:1557] [KO:K17721]
CYP2D6 [HSA:1565] [KO:K17712]

Comment

In Caucasians and Asians, PM and allele frequency levels of CYPs (CYP2A6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) are summarized from previous findings.

Other DBs

MeSH:

C563703 C563835

OMIM:

Reference

Authors

Mizutani T

Title

PM frequencies of major CYPs in Asians and Caucasians.

Journal

Drug Metab Rev 35:99-106 (2003)
DOI:10.1081/DMR-120023681

Reference

Authors

Gaikovitch EA, Cascorbi I, Mrozikiewicz PM, Brockmoller J, Frotschl R, Kopke K, Gerloff T, Chernov JN, Roots I

Title

Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population.

Journal

Eur J Clin Pharmacol 59:303-12 (2003)
DOI:10.1007/s00228-003-0606-2

Reference

Authors

Kaneko A, Kaneko O, Taleo G, Bjorkman A, Kobayakawa T

Title

High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu.

Journal

Lancet 349:921-2 (1997)
DOI:10.1016/S0140-6736(05)62696-7

LinkDB

» Japanese version

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