KEGG   DISEASE: Atherosclerosis
Entry
H02505                      Disease                                
Name
Atherosclerosis
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke. Atherosclerosis develops as a result of the interactions of various genetic and environmental factors. Elevated cholesterol and LDLcholesterol (LDL-C) levels are the main risk factors that associated with the formation of atherosclerotic plaques and the development of atherosclerosis.
Category
Cardiovascular disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 11 Diseases of the circulatory system
  Diseases of arteries or arterioles
   Chronic arterial occlusive disease
    BD40  Atherosclerotic chronic arterial occlusive disease
     H02505  Atherosclerosis
Disease
pathway
hsa05417  Lipid and atherosclerosis
Pathway
hsa04975  Fat digestion and absorption
hsa04979  Cholesterol metabolism
Gene
LDLR [HSA:3949] [KO:K12473]
APOB [HSA:338] [KO:K14462]
PCSK9 [HSA:255738] [KO:K13050]
LDLRAP1 [HSA:26119] [KO:K12474]
ABCG5 [HSA:64240] [KO:K05683]
ABCG8 [HSA:64241] [KO:K05684]
LCAT [HSA:3931] [KO:K00650]
ABCA1 [HSA:19] [KO:K05641]
APOA1 [HSA:335] [KO:K08757]
MEF2A [HSA:4205] [KO:K09260]
LRP6 [HSA:4040] [KO:K03068]
Drug
Inclisiran [DR:D11931]
Inclisiran sodium [DR:D12293]
Other DBs
ICD-11: BD40
MeSH: D050197
Reference
PMID:19301036
  Authors
Roy H, Bhardwaj S, Yla-Herttuala S
  Title
Molecular genetics of atherosclerosis.
  Journal
Hum Genet 125:467-91 (2009)
DOI:10.1007/s00439-009-0654-5
Reference
PMID:15485348
  Authors
Lusis AJ, Mar R, Pajukanta P
  Title
Genetics of atherosclerosis.
  Journal
Annu Rev Genomics Hum Genet 5:189-218 (2004)
DOI:10.1146/annurev.genom.5.061903.175930
Reference
PMID:30276232
  Authors
Jackson AO, Regine MA, Subrata C, Long S
  Title
Molecular mechanisms and genetic regulation in atherosclerosis.
  Journal
Int J Cardiol Heart Vasc 21:36-44 (2018)
DOI:10.1016/j.ijcha.2018.09.006
Reference
PMID:32378144
  Authors
Koushki K, Shahbaz SK, Mashayekhi K, Sadeghi M, Zayeri ZD, Taba MY, Banach M, Al-Rasadi K, Johnston TP, Sahebkar A
  Title
Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways.
  Journal
Clin Rev Allergy Immunol 10.1007/s12016-020-08791-9 (2020)
DOI:10.1007/s12016-020-08791-9
LinkDB

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