KEGG   DRUG: Noradrenaline
Entry
D00076                      Drug                                   
Name
Noradrenaline (JP18);
Norepinephrine (INN);
Nor adrenalin (TN)
Formula
C8H11NO3
Exact mass
169.0739
Mol weight
169.1778
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01592  COMT substrate
 DG02917  MAO substrate
Remark
Same as: C00547
Therapeutic category: 2451
ATC code: C01CA03
Chemical structure group: DG00212
Product (DG00212): D00076<JP> D05206<US>
Efficacy
Antihypotensive, Vasoconstrictor, Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: COMT [HSA:1312], MAO [HSA:4128 4129]
Interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D00076  Noradrenaline (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2451  Epinephrines
     D00076  Noradrenaline (JP18); Norepinephrine (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00212  Norepinephrine
     D00076  Noradrenaline
  DG01456  Adrenergic receptor agonist
   DG00212  Norepinephrine
    D00076  Noradrenaline
  DG01951  Catecholamine adrenergic receptor agonist
   DG00212  Norepinephrine
    D00076  Noradrenaline
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00212  Norepinephrine
    D00076  Noradrenaline
  DG02917  MAO substrate
   DG00212  Norepinephrine
    D00076  Noradrenaline
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00076  Noradrenaline (JP18) <JP>
    ADRA2
     D00076  Noradrenaline (JP18) <JP>
    ADRB
     D00076  Noradrenaline (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00076  Noradrenaline
  D00076  Noradrenaline injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00076
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00212  Norepinephrine
  DG01456  Adrenergic receptor agonist
   DG00212  Norepinephrine
  DG01951  Catecholamine adrenergic receptor agonist
   DG00212  Norepinephrine
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00212  Norepinephrine
  DG02917  MAO substrate
   DG00212  Norepinephrine
Other DBs
CAS: 51-41-2
PubChem: 7847144
ChEBI: 18357
PDB-CCD: E5E[PDBj] LNR[PDBj]
LigandBox: D00076
NIKKAJI: J9.223A
LinkDB
KCF data

ATOM        12
            1   C8y C    25.1107  -17.0137
            2   C8x C    25.1107  -18.4285
            3   C8x C    23.8950  -16.3188
            4   C1c C    26.3149  -16.3188
            5   C8x C    23.8950  -19.1423
            6   C8y C    22.6850  -17.0137
            7   C1b C    27.5246  -17.0080
            8   O1a O    26.3149  -14.9217
            9   C8y C    22.6850  -18.4285
            10  N1a N    28.7227  -16.3130
            11  O1a O    21.4681  -19.1189
            12  O1a O    21.4728  -16.3208
BOND        12
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1 #Up
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1

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