| Entry |
|
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| Name |
Ebastine (JP18/USAN/INN);
Kestine (TN) |
|---|
| Formula |
C32H39NO2
|
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| Exact mass |
469.2981
|
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| Mol weight |
469.66
|
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| Structure |
|
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG02954 CYP2J2 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 4490 |
|
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| Efficacy |
Antiallergic, Antipruritic, H1 receptor antagonist |
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
|---|
| Metabolism |
Enzyme: CYP2J2 [HSA: 1573], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AX Other antihistamines for systemic use
R06AX22 Ebastine
D01478 Ebastine (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
449 Miscellaneous
4490 Miscellaneous
D01478 Ebastine (JP18/USAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for otolaryngologic use
69 Oral medicine for nasal inflammation
D01478 Ebastine (JP18/USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Ebastine
D01478 Ebastine (JP18/USAN/INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
D01478 Ebastine
Dermatological agent
DG03243 Atopic dermatitis agent
D01478 Ebastine
Metabolizing enzyme substrate
DG02954 CYP2J2 substrate
D01478 Ebastine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01478 Ebastine
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D01478 Ebastine
Dermatological agent
DG03243 Atopic dermatitis agent
D01478 Ebastine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D01478 Ebastine (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01478 Ebastine
D01478 Ebastine tablets
D01478 Ebastine orally disintegrating tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01478
Rx-to-OTC switch list in Japan [br08314.html]
D01478
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 35
1 C8y C 34.2938 -13.6276
2 C8x C 35.5095 -14.3273
3 C8x C 36.7234 -13.6244
4 C8y C 36.7215 -12.2217
5 C8x C 35.5058 -11.5220
6 C8x C 34.2919 -12.2249
7 C1d C 37.9408 -11.5356
8 C8x C 20.9617 -18.5185
9 C8x C 20.9617 -19.9179
10 C8x C 22.1765 -20.6176
11 C8x C 23.3843 -19.9179
12 C8y C 23.3843 -18.5185
13 C8x C 22.1765 -17.8188
14 C1c C 24.5968 -17.8196
15 C8y C 25.8081 -18.5204
16 O2a O 24.5978 -16.4202
17 C8x C 25.8017 -19.9178
18 C8x C 27.0130 -20.6183
19 C8x C 28.2255 -19.9196
20 C8x C 28.2265 -18.5202
21 C8x C 27.0150 -17.8195
22 C1y C 25.8103 -15.7215
23 C1x C 27.0199 -16.4210
24 C1x C 28.2324 -15.7223
25 N1y N 28.2335 -14.3229
26 C1x C 27.0220 -13.6222
27 C1x C 25.8096 -14.3210
28 C1b C 29.4460 -13.6240
29 C1b C 30.6574 -14.3246
30 C1b C 31.8700 -13.6259
31 C5a C 33.0813 -14.3265
32 O5a O 33.0802 -15.7259
33 C1a C 39.1533 -10.8356
34 C1a C 38.6402 -12.7623
35 C1a C 37.2535 -10.3299
BOND 38
1 5 6 1
2 6 1 2
3 4 7 1
4 1 2 1
5 11 12 1
6 12 13 2
7 13 8 1
8 15 17 2
9 17 18 1
10 18 19 2
11 19 20 1
12 20 21 2
13 21 15 1
14 16 22 1
15 12 14 1
16 14 15 1
17 8 9 2
18 14 16 1
19 22 23 1
20 23 24 1
21 24 25 1
22 25 26 1
23 26 27 1
24 27 22 1
25 9 10 1
26 25 28 1
27 10 11 2
28 28 29 1
29 29 30 1
30 2 3 2
31 30 31 1
32 31 1 1
33 3 4 1
34 31 32 2
35 4 5 2
36 7 33 1
37 7 34 1
38 7 35 1
|
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