Entry
Name
Ubiquitin mediated proteolysis - Mus musculus (house mouse)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
22186 Uba52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927 ]
22196 Ube2i; ubiquitin-conjugating enzyme E2I [KO:K10577 ]
17999 Nedd4; neural precursor cell expressed, developmentally down-regulated 4 [KO:K10591 ] [EC:2.3.2.26 ]
83814 Nedd4l; neural precursor cell expressed, developmentally down-regulated gene 4-like [KO:K13305 ] [EC:2.3.2.26 ]
235439 Herc1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [KO:K10594 ] [EC:2.3.2.26 ]
15204 Herc2; HECT and RLD domain containing E3 ubiquitin protein ligase 2 [KO:K10595 ] [EC:2.3.2.26 ]
18854 Pml; promyelocytic leukemia [KO:K10054 ] [EC:2.3.2.-]
11797 Birc2; baculoviral IAP repeat-containing 2 [KO:K16060 ]
11796 Birc3; baculoviral IAP repeat-containing 3 [KO:K16060 ]
329581 Birc7; baculoviral IAP repeat-containing 7 [KO:K16061 ]
56469 Pias1; protein inhibitor of activated STAT 1 [KO:K04706 ] [EC:2.3.2.-]
17344 Pias2; protein inhibitor of activated STAT 2 [KO:K16063 ] [EC:2.3.2.-]
229615 Pias3; protein inhibitor of activated STAT 3 [KO:K16064 ] [EC:2.3.2.-]
21402 Skp1; S-phase kinase-associated protein 1 [KO:K03094 ]
103583 Fbxw11; F-box and WD-40 domain protein 11 [KO:K03362 ]
12234 Btrc; beta-transducin repeat containing protein [KO:K03362 ]
27401 Skp2; S-phase kinase-associated protein 2 [KO:K03875 ]
50754 Fbxw7; F-box and WD-40 domain protein 7 [KO:K10260 ]
22346 Vhl; von Hippel-Lindau tumor suppressor [KO:K03871 ]
50868 Keap1; kelch-like ECH-associated protein 1 [KO:K10456 ]
246710 Rhobtb2; Rho-related BTB domain containing 2 [KO:K07868 ]
69288 Rhobtb1; Rho-related BTB domain containing 1 [KO:K07868 ]
13194 Ddb1; damage specific DNA binding protein 1 [KO:K10610 ]
107986 Ddb2; damage specific DNA binding protein 2 [KO:K10140 ]
71991 Ercc8; excision repaiross-complementing rodent repair deficiency, complementation group 8 [KO:K10570 ]
76375 Det1; DET1 partner of COP1 E3 ubiquitin ligase [KO:K10571 ]
12703 Socs1; suppressor of cytokine signaling 1 [KO:K04694 ]
12702 Socs3; suppressor of cytokine signaling 3 [KO:K04696 ]
66156 Anapc11; anaphase promoting complex subunit 11 [KO:K03358 ]
99152 Anapc2; anaphase promoting complex subunit 2 [KO:K03349 ]
56371 Fzr1; fizzy and cell division cycle 20 related 1 [KO:K03364 ]
17222 Anapc1; anaphase promoting complex subunit 1 [KO:K03348 ]
52206 Anapc4; anaphase promoting complex subunit 4 [KO:K03351 ]
59008 Anapc5; anaphase-promoting complex subunit 5 [KO:K03352 ]
56317 Anapc7; anaphase promoting complex subunit 7 [KO:K03354 ]
68999 Anapc10; anaphase promoting complex subunit 10 [KO:K03357 ]
69010 Anapc13; anaphase promoting complex subunit 13 [KO:K12456 ]
75430 Anapc15; anaphase promoting complex C subunit 15 [KO:K25228 ]
52717 Anapc16; anaphase promoting complex subunit 16 [KO:K25229 ]
Reference
Authors
Kamura T.
Title
[Cullin-based E3 family]
Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
Authors
Matsuda N.
Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
Authors
Tokunaga F.
Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
Authors
Nalepa G, Rolfe M, Harper JW.
Title
Drug discovery in the ubiquitin-proteasome system.
Journal
Reference
Authors
Hsu YJ, Goodman SR.
Title
Spectrin and ubiquitination: a review.
Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
Authors
Hatakeyama S, Nakayama KI.
Title
Ubiquitylation as a quality control system for intracellular proteins.
Journal
Reference
Authors
Lee J, Zhou P.
Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
Journal
Related pathway
KO pathway
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