KEGG GLYCAN: G00046

GLYCAN: G00046

Entry

G00046                      Glycan

Name

Fuc-Lc4Cer;
III4-a-Fuc-Lc4Cer;
Lea glycolipid

Composition

(Gal)2 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1

Mass

835.8 (Cer)

Structure

Remark

Same as:

C22470

Reaction

R06155

Pathway

map00601

Glycosphingolipid biosynthesis - lacto and neolacto series

map01100

Metabolic pathways

Network

nt06035 Blood group carbohydrate antigen biosynthesis

Enzyme

2.4.1.65

Brite

Lipids [BR:br08002]
SP  Sphingolipids
  SP05 Neutral glycosphingolipids
   SP0504 Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc- (Lacto series)
    G00046  Fuc-alpha1->4(Gal-beta1->3)GlcNAc-beta1->3LacCer
Blood groups and carbohydrate antigens [br08110.html]
Lewis blood group
  G00046

Reference

1 [PMID:3392043]

Authors

Larson G, Falk P, Hoskins LC.

Title

Degradation of human intestinal glycosphingolipids by extracellular glycosidases from mucin-degrading bacteria of the human fecal flora.

Journal

J Biol Chem 263:10790-8 (1988)

Reference

2 [PMID:9111138]

Authors

Henry S, Jovall PA, Ghardashkhani S, Elmgren A, Martinsson T, Larson G, Samuelsson B.

Title

Structural and immunochemical identification of Le(a), Le(b), H type 1, and related glycolipids in small intestinal mucosa of a group O Le(a-b-) nonsecretor.

Journal

Glycoconj J 14:209-23 (1997)
DOI:10.1023/a:1018541821819

Reference

3 [PMID:2960671]

Authors

Holmes EH, Hakomori S, Ostrander GK.

Title

Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.

Journal

J Biol Chem 262:15649-58 (1987)

Other DBs

CCSD:

913 2679 5564 8362 8725 12328 13369 14017 14077 14540 14900 15610 16291 16411 16468 16573 18429 18485 19368 21112 21740 21918 23893 23916 25514 33040 33054 34831 36049 36051 36114 37574 43884 48138 50495

GlyTouCan:

LIPIDMAPS:

JCGGDB:

LipidBank:

GlycoEpitope:

LinkDB

KCF data

NODE        6
            1   Cer        13     0
            2   Glc         5     0
            3   Gal        -3     0
            4   GlcNAc    -12     0
            5   Gal       -20    -4
            6   LFuc      -21     4
EDGE        5
            1     2:b1    1:1
            2     3:b1    2:4
            3     4:b1    3:3
            4     5:b1    4:3
            5     6:a1    4:4

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