KEGG   PATHWAY: dre00062
Entry
dre00062                    Pathway                                
Name
Fatty acid elongation - Danio rerio (zebrafish)
Class
Metabolism; Lipid metabolism
Pathway map
dre00062  Fatty acid elongation
dre00062

Module
dre_M00085  Fatty acid elongation in mitochondria [PATH:dre00062]
dre_M00415  Fatty acid elongation in endoplasmic reticulum [PATH:dre00062]
Other DBs
GO: 0030497
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
406325  acaa2; 3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
336606  hadhb; trifunctional enzyme subunit beta, mitochondrial [KO:K07509] [EC:2.3.1.16]
445121  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
793834  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b [KO:K07515] [EC:4.2.1.17 1.1.1.211]
553401  hadhaa; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a [KO:K07515] [EC:4.2.1.17 1.1.1.211]
368912  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
550550  mecr; enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor [KO:K07512] [EC:1.3.1.- 1.3.1.38]
101884755  enoyl-[acyl-carrier-protein] reductase, mitochondrial-like isoform X1 [KO:K07512] [EC:1.3.1.- 1.3.1.38]
406648  ppt1; palmitoyl-protein thioesterase 1 precursor [KO:K01074] [EC:3.1.2.22]
393135  ppt2a.2; Lysosomal thioesterase PPT2-A-like precursor [KO:K01074] [EC:3.1.2.22]
393657  ppt2a.1; lysosomal thioesterase PPT2a.1 precursor [KO:K01074] [EC:3.1.2.22]
405845  ppt2a.4; uncharacterized protein LOC405845 precursor [KO:K01074] [EC:3.1.2.22]
100126133  ppt2b; lysosomal thioesterase PPT2 precursor [KO:K01074] [EC:3.1.2.22]
406830  ppt2a.3; uncharacterized protein LOC406830 precursor [KO:K01074] [EC:3.1.2.22]
406725  elovl1b; elongation of very long chain fatty acids protein 1b [KO:K10247] [EC:2.3.1.199]
449816  elovl1a; elongation of very long chain fatty acids protein 1a [KO:K10247] [EC:2.3.1.199]
678614  elovl2; elongation of very long chain fatty acids protein 2 [KO:K10205] [EC:2.3.1.199]
335732  elovl4b; elongation of very long chain fatty acids protein 4b [KO:K10249] [EC:2.3.1.199]
393769  elovl4a; elongation of very long chain fatty acids protein 4a [KO:K10249] [EC:2.3.1.199]
554145  elovl8b; ELOVL fatty acid elongase 8b [KO:K10249] [EC:2.3.1.199]
767653  elovl8a; ELOVL fatty acid elongase 8a [KO:K10249] [EC:2.3.1.199]
393425  elovl5; elongation of very long chain fatty acids protein 5 [KO:K10244] [EC:2.3.1.199]
317738  elovl6; very long chain fatty acid elongase 6 [KO:K10203] [EC:2.3.1.199]
100150288  elovl6l; elongation of very long chain fatty acids protein 6-like [KO:K10203] [EC:2.3.1.199]
334217  elovl7a; elongation of very long chain fatty acids protein 7a [KO:K10250] [EC:2.3.1.199]
327274  elovl7b; very long chain fatty acid elongase 7 [KO:K10250] [EC:2.3.1.199]
322626  hsd17b12b; very-long-chain 3-oxoacyl-CoA reductase-B [KO:K10251] [EC:1.1.1.62 1.1.1.330]
327417  hsd17b12a; very-long-chain 3-oxoacyl-CoA reductase-A [KO:K10251] [EC:1.1.1.62 1.1.1.330]
368367  hsd20b2; hydroxysteroid (20-beta) dehydrogenase 2 [KO:K10251] [EC:1.1.1.62 1.1.1.330]
334121  hacd2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 [KO:K10703] [EC:4.2.1.134]
553326  hacd1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 [KO:K10703] [EC:4.2.1.134]
561303  hacd4; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 [KO:K10703] [EC:4.2.1.134]
393441  hacd3; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [KO:K10703] [EC:4.2.1.134]
450002  tecrl2b; trans-2,3-enoyl-CoA reductase-like 2b [KO:K10258] [EC:1.3.1.93]
326954  tecrb; trans-2,3-enoyl-CoA reductase b [KO:K10258] [EC:1.3.1.93]
798606  tecrl2a; very-long-chain enoyl-CoA reductase-like isoform X1 [KO:K10258] [EC:1.3.1.93]
566085  tecra; very-long-chain enoyl-CoA reductase [KO:K10258] [EC:1.3.1.93]
553440  acot20; acyl-coenzyme A thioesterase 1 [KO:K01068] [EC:3.1.2.2]
562047  acot21; acyl-coenzyme A thioesterase 1 [KO:K01068] [EC:3.1.2.2]
492778  acot19; acyl-CoA thioesterase 19 [KO:K01068] [EC:3.1.2.2]
447878  acot7; cytosolic acyl coenzyme A thioester hydrolase [KO:K17360] [EC:3.1.2.2]
791152  them4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
Compound
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00083  Malonyl-CoA
C00136  Butanoyl-CoA
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00249  Hexadecanoic acid
C00264  3-Oxoacyl-CoA
C00605  2,3-Dehydroacyl-CoA
C00638  Long-chain fatty acid
C00640  (3S)-3-Hydroxyacyl-CoA
C00658  trans-2,3-Dehydroacyl-CoA
C01832  Lauroyl-CoA
C01944  Octanoyl-CoA
C02593  Tetradecanoyl-CoA
C02843  Long-chain acyl-CoA
C03221  2-trans-Dodecenoyl-CoA
C05258  (S)-3-Hydroxyhexadecanoyl-CoA
C05259  3-Oxopalmitoyl-CoA
C05260  (S)-3-Hydroxytetradecanoyl-CoA
C05261  3-Oxotetradecanoyl-CoA
C05262  (S)-3-Hydroxydodecanoyl-CoA
C05263  3-Oxododecanoyl-CoA
C05264  (S)-Hydroxydecanoyl-CoA
C05265  3-Oxodecanoyl-CoA
C05266  (S)-3-Hydroxyoctanoyl-CoA
C05267  3-Oxooctanoyl-CoA
C05268  (S)-Hydroxyhexanoyl-CoA
C05269  3-Oxohexanoyl-CoA
C05270  Hexanoyl-CoA
C05271  trans-Hex-2-enoyl-CoA
C05272  trans-Hexadec-2-enoyl-CoA
C05273  trans-Tetradec-2-enoyl-CoA
C05274  Decanoyl-CoA
C05275  trans-Dec-2-enoyl-CoA
C05276  trans-Oct-2-enoyl-CoA
C20876  Very-long-chain acyl-CoA
C20877  Very-long-chain 3-oxoacyl-CoA
C20878  Very-long-chain (3R)-3-hydroxyacyl-CoA
C20879  Very-long-chain trans-2,3-dehydroacyl-CoA
Reference
PMID:4387390
  Authors
Seubert W, Lamberts I, Kramer R, Ohly B
  Title
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA.
  Journal
Biochim Biophys Acta 164:498-517 (1968)
DOI:10.1016/0005-2760(68)90180-X
Reference
PMID:7150615
  Authors
El-Fakhri M, Middleton B
  Title
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.
  Journal
Biochim Biophys Acta 713:270-9 (1982)
DOI:10.1016/0005-2760(82)90244-2
Reference
PMID:8190743
  Authors
Cassagne C, Lessire R, Bessoule JJ, Moreau P, Creach A, Schneider F, Sturbois B
  Title
Biosynthesis of very long chain fatty acids in higher plants.
  Journal
Prog Lipid Res 33:55-69 (1994)
DOI:10.1016/0163-7827(94)90009-4
Reference
PMID:16564093
  Authors
Jakobsson A, Westerberg R, Jacobsson A.
  Title
Fatty acid elongases in mammals: their regulation and roles in metabolism.
  Journal
Prog Lipid Res 45:237-49 (2006)
DOI:10.1016/j.plipres.2006.01.004
Reference
PMID:16765910
  Authors
Blacklock BJ, Jaworski JG
  Title
Substrate specificity of Arabidopsis 3-ketoacyl-CoA synthases.
  Journal
Biochem Biophys Res Commun 346:583-90 (2006)
DOI:10.1016/j.bbrc.2006.05.162
Reference
PMID:16866954
  Authors
Shepherd T, Wynne Griffiths D
  Title
The effects of stress on plant cuticular waxes.
  Journal
New Phytol 171:469-99 (2006)
DOI:10.1111/j.1469-8137.2006.01826.x
Reference
PMID:17719534
  Authors
Riezman H
  Title
The long and short of fatty acid synthesis.
  Journal
Cell 130:587-8 (2007)
DOI:10.1016/j.cell.2007.08.008
Reference
PMID:19649180
  Authors
Raffaele S, Leger A, Roby D
  Title
Very long chain fatty acid and lipid signaling in the response of plants to pathogens.
  Journal
Plant Signal Behav 4:94-9 (2009)
DOI:10.4161/psb.4.2.7580
Related
pathway
dre00071  Fatty acid degradation
KO pathway
ko00062   
LinkDB

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