KEGG   PATHWAY: dre03320
Entry
dre03320                    Pathway                                
Name
PPAR signaling pathway - Danio rerio (zebrafish)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
dre03320  PPAR signaling pathway
dre03320

Organism
Danio rerio (zebrafish) [GN:dre]
Gene
436636  cd36; platelet glycoprotein 4 [KO:K06259]
541410  slc27a1a; long-chain fatty acid transport protein 1a [KO:K08745] [EC:6.2.1.-]
553512  slc27a1b; long-chain fatty acid transport protein 1b [KO:K08745] [EC:6.2.1.-]
550432  slc27a4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
494096  zgc:101540; hsFATP2a_ACSVL_like domain-containing protein [KO:K08746] [EC:6.2.1.- 6.2.1.3]
100009650  zgc:158482; uncharacterized protein LOC100009650 precursor [KO:K08746] [EC:6.2.1.- 6.2.1.3]
449925  slc27a2a; solute carrier family 27 member 2a [KO:K08746] [EC:6.2.1.- 6.2.1.3]
100004228  slc27a2b; very long-chain acyl-CoA synthetase precursor [KO:K08746] [EC:6.2.1.- 6.2.1.3]
568883  long-chain fatty acid transport protein 6-like [KO:K08749]
568835  slc27a6; long-chain fatty acid transport protein 6 precursor [KO:K08749]
791610  fabp1a; fatty acid binding protein 1-A, liver [KO:K08750]
554095  fabp1b.1; fatty acid binding protein 1-B.1 [KO:K08750]
30708  fabp2; fatty acid-binding protein, intestinal [KO:K08751]
171478  fabp3; fatty acid-binding protein, heart [KO:K08752]
447944  fabp4a; fatty acid binding protein 4a [KO:K08752]
553579  fabp4b; fatty acid binding protein 4b [KO:K08753]
415166  fabp6; gastrotropin [KO:K08755]
407736  fabp7b; fatty acid binding protein 7, brain, b [KO:K08756]
58128  fabp7a; fatty acid binding protein 7, brain, a [KO:K08756]
557714  pparab; peroxisome proliferator-activated receptor alpha b [KO:K07294]
563298  pparaa; peroxisome proliferator-activated receptor alpha a [KO:K07294]
555578  rxraa; retinoic acid receptor RXR-alpha-A [KO:K08524]
30464  rxrga; retinoic acid receptor RXR-gamma-A [KO:K08524]
30530  rxrba; retinoic acid receptor RXR-beta-A isoform 2 [KO:K08525]
436617  rxrgb; retinoic acid receptor RXR-gamma-B [KO:K08526]
30754  ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504]
30750  pparda; peroxisome proliferator-activated receptor delta [KO:K04504]
557037  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
394060  hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
30355  apoa1a; apolipoprotein A-I precursor [KO:K08757]
100101640  apoa1b; apolipoprotein A-Ib precursor [KO:K08757]
568656  type-4 ice-structuring protein LS-12 precursor [KO:K08758]
568707  afp4; antifreeze protein type IV precursor [KO:K08758]
445125  pltp; phospholipid transfer protein precursor [KO:K08761]
492719  me3; NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
768196  me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
140615  fads2; acyl-CoA 6-desaturase [KO:K10226] [EC:1.14.19.3]
386661  scd; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
553734  scdb; stearoyl-CoA desaturase b [KO:K00507] [EC:1.14.19.1]
394148  cyp7a1; cytochrome P450 7A1 [KO:K00489] [EC:1.14.14.23]
559097  cyp7a1b; cholesterol 7-alpha-monooxygenase [KO:K00489] [EC:1.14.14.23]
445281  cyp8b1.1; 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
447848  cyp8b1.3; cytochrome P450 8B3 [KO:K07431] [EC:1.14.14.139]
100004274  cyp8b1.2; cytochrome P450 8B2 [KO:K07431] [EC:1.14.14.139]
548341  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
565876  cyp27a3; cytochrome P450 [KO:K00488] [EC:1.14.15.15]
795106  cyp27a1.2; sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:1.14.15.15]
322341  cyp27a1.4; cytochrome P450 27A1.4 [KO:K00488] [EC:1.14.15.15]
723999  zgc:136333; uncharacterized protein LOC723999 [KO:K00488] [EC:1.14.15.15]
558239  si:ch211-113j14.1; cytochrome P450 27C1 [KO:K00488] [EC:1.14.15.15]
402831  cyp27a7; sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:1.14.15.15]
393831  dbi; acyl-CoA-binding protein isoform 2 [KO:K08762]
30354  lpla; lipoprotein lipase precursor [KO:K01059] [EC:3.1.1.34]
100331214  lipoprotein lipase-like isoform X1 [KO:K01059] [EC:3.1.1.34]
101884800  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
393622  acsl4a; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
447860  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
555308  acsl1a; long-chain-fatty-acid--CoA ligase 1a [KO:K01897] [EC:6.2.1.3]
559656  acsl3b; long-chain-fatty-acid--CoA ligase 3b [KO:K01897] [EC:6.2.1.3]
566863  acsl6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
445175  acsl1b; long-chain-fatty-acid--CoA ligase 1b [KO:K01897] [EC:6.2.1.3]
334561  acsl4b; long-chain-fatty-acid--CoA ligase 4b [KO:K01897] [EC:6.2.1.3]
567157  acsl3a; long-chain-fatty-acid--CoA ligase 3a [KO:K01897] [EC:6.2.1.3]
100332846  acsl2; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
100006023  acsbg1; long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1 [KO:K15013] [EC:6.2.1.3]
335159  acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 [KO:K15013] [EC:6.2.1.3]
100000859  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
431754  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
393839  scp2a; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
406421  acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
449662  acox1; peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
560000  cpt1ab; carnitine O-palmitoyltransferase 1, liver isoform isoform X2 [KO:K08765] [EC:2.3.1.21]
558088  cpt1aa; carnitine palmitoyltransferase 1Aa (liver) [KO:K08765] [EC:2.3.1.21]
100333227  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
449677  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
550361  cpt1cb; carnitine O-palmitoyltransferase 1, liver isoform isoform X2 [KO:K08765] [EC:2.3.1.21]
100005717  cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
394156  acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
406283  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
492647  angptl4; angiopoietin-related protein 4 precursor [KO:K08767]
100002756  sorbs1; sorbin and SH3 domain-containing protein 1 isoform X5 [KO:K06086]
100034463  plin1; perilipin-1 isoform X1 [KO:K08768]
794841  plin2; perilipin-2 [KO:K17284]
562602  adipoqa; adiponectin [KO:K07296]
751715  adipoqb; adiponectin, C1Q and collagen domain containing, b precursor [KO:K07296]
393543  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
403000  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
768202  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a precursor [KO:K06276] [EC:2.7.11.1]
777766  ubc; polyubiquitin-C [KO:K08770]
550134  ubb; polyubiquitin-B [KO:K08770]
378727  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
406473  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
100136866  zgc:172295; glycerol kinase [KO:K00864] [EC:2.7.1.30]
334529  aqp7; aquaporin-7 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
dre00071  Fatty acid degradation
dre00120  Primary bile acid biosynthesis
dre00564  Glycerophospholipid metabolism
dre04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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