KEGG   PATHWAY: dre04070
Entry
dre04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Danio rerio (zebrafish)
Class
Environmental Information Processing; Signal transduction
Pathway map
dre04070  Phosphatidylinositol signaling system
dre04070

Organism
Danio rerio (zebrafish) [GN:dre]
Gene
556956  pi4kaa; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
563201  pi4kb; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
564750  pi4k2b; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
406667  pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
791142  sacm1lb; phosphatidylinositol-3-phosphatase SAC1-B [KO:K21797] [EC:3.1.3.-]
558940  sacm1la; phosphatidylinositol-3-phosphatase SAC1-A [KO:K21797] [EC:3.1.3.-]
570007  inpp5f; phosphatidylinositide phosphatase SAC2 [KO:K21798] [EC:3.1.3.-]
449831  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
553629  pip5k1aa; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a [KO:K00889] [EC:2.7.1.68]
492549  pip5k1ab; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
447840  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
798876  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
100005033  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b [KO:K00889] [EC:2.7.1.68]
777716  ocrl; inositol polyphosphate 5-phosphatase OCRL [KO:K01099] [EC:3.1.3.36]
563543  inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
606579  inpp5e; phosphatidylinositol polyphosphate 5-phosphatase type IV [KO:K20278] [EC:3.1.3.36]
337236  synj1; synaptojanin-1 [KO:K20279] [EC:3.1.3.36]
394174  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
561737  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100002263  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
404211  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100000252  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
557176  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
368415  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
794088  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
559103  inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
325179  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
368433  inppl1b; inositol polyphosphate phosphatase-like 1b [KO:K15909] [EC:3.1.3.86]
792527  inpp4ab; inositol polyphosphate-4-phosphatase type I Ab [KO:K01109] [EC:3.1.3.66]
560006  inpp4b; type II inositol 3,4-bisphosphate 4-phosphatase isoform X3 [KO:K01109] [EC:3.1.3.66]
664741  inpp4aa; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
337690  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
560881  mtm1; myotubularin isoform 1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
30644  mtmr2; myotubularin-related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
541517  mtmr1b; myotubularin-related protein 1b [KO:K18081] [EC:3.1.3.64 3.1.3.95]
553750  mtmr1a; myotubularin-related protein 1a [KO:K18081] [EC:3.1.3.64 3.1.3.95]
100333801  myotubularin-related protein 3-like [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
393584  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
393838  mtmr3; myotubularin-related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
327346  mtmr6; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
393365  mtmr8; myotubularin-related protein 8 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
559198  mtmr7b; myotubularin-related protein 7b [KO:K18083] [EC:3.1.3.64 3.1.3.95]
678558  mtmr7a; myotubularin-related protein 7a [KO:K18083] [EC:3.1.3.64 3.1.3.95]
323929  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
373124  pip4k2ca; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
560360  pip4k2aa; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
100535634  pip4k2cb; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like isoform X1 [KO:K00920] [EC:2.7.1.149]
555920  pip4k2ab; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
556136  pip4p1a; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A [KO:K13084] [EC:3.1.3.78]
566642  pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
553253  pip4p1b; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B [KO:K13084] [EC:3.1.3.78]
548346  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
571356  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
100330514  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
567938  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
100001532  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100537538  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
569376  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100149080  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
407700  plcb4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
337489  plcd1b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b [KO:K05857] [EC:3.1.4.11]
569040  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
555443  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a [KO:K05857] [EC:3.1.4.11]
565669  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
562569  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
568288  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
373867  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
561747  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
790916  ipmkb; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
100151036  ipmka; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
563019  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
562919  itpkca; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
322720  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
368717  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101884388  inpp5a; type I inositol 1,4,5-trisphosphate 5-phosphatase [KO:K01106] [EC:3.1.3.56]
406290  itpk1a; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
100148744  itpk1b; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
541511  ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
322041  ip6k2a; inositol hexakisphosphate kinase 2a [KO:K07756] [EC:2.7.4.21]
564478  ip6k1; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
436662  ip6k2b; inositol hexakisphosphate kinase 2b [KO:K07756] [EC:2.7.4.21]
556748  ppip5k1a; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4 [KO:K13024] [EC:2.7.4.24]
449862  ppip5k2; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X4 [KO:K13024] [EC:2.7.4.24]
559938  ppip5k1b; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X7 [KO:K13024] [EC:2.7.4.24]
555899  si:ch211-160o17.2; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
553595  impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
437018  impa1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
641570  bpnt2; inositol monophosphatase 3 [KO:K15759] [EC:3.1.3.7]
553380  dgkza; diacylglycerol kinase zeta isoform X6 [KO:K00901] [EC:2.7.1.107]
100150463  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
724010  dgkaa; diacylglycerol kinase, alpha a [KO:K00901] [EC:2.7.1.107]
567728  diacylglycerol kinase beta isoform X2 [KO:K00901] [EC:2.7.1.107]
557324  dgkb; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
100536469  diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
100331649  dgki; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
100137124  dgkh; diacylglycerol kinase eta isoform X5 [KO:K00901] [EC:2.7.1.107]
565122  si:dkey-172j4.3; diacylglycerol kinase delta isoform X2 [KO:K00901] [EC:2.7.1.107]
564739  dgkab; diacylglycerol kinase, alpha b [KO:K00901] [EC:2.7.1.107]
100148835  dgkzb; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
394161  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
100002015  cds1; phosphatidate cytidylyltransferase 1 isoform X1 [KO:K00981] [EC:2.7.7.41]
404620  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
100149388  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
567611  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
562585  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
794666  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
497384  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
100333967  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100006675  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
393953  prkcbb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100003514  prkcg; protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
321808  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
192322  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
368217  calm1b; calmodulin-1b [KO:K02183]
406660  calm1a; calmodulin-1a [KO:K02183]
336121  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
327379  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
560151  calml4a; calmodulin-like protein 4a [KO:K02183]
100321746  calml4b; calmodulin-like protein 4 [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
dre04020  Calcium signaling pathway
dre04144  Endocytosis
dre04510  Focal adhesion
KO pathway
ko04070   
LinkDB

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