KEGG   PATHWAY: dre04910
Entry
dre04910                    Pathway                                
Name
Insulin signaling pathway - Danio rerio (zebrafish)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
dre04910  Insulin signaling pathway
dre04910

Organism
Danio rerio (zebrafish) [GN:dre]
Gene
30262  ins; insulin preproprotein [KO:K04526]
566735  insb; preproinsulin b precursor [KO:K04526]
100534937  LOW QUALITY PROTEIN: insulin-like [KO:K04526]
245699  insra; insulin receptor a precursor [KO:K04527] [EC:2.7.10.1]
245700  insrb; insulin receptor b precursor [KO:K04527] [EC:2.7.10.1]
559281  irs1; insulin receptor substrate 1 [KO:K16172]
393285  irs2a; insulin receptor substrate 2a [KO:K07187]
572001  irs2b; insulin receptor substrate 2 [KO:K07187]
100329897  irs4a; insulin receptor substrate 2-B [KO:K07187]
794462  LOW QUALITY PROTEIN: insulin receptor substrate 2-B-like [KO:K07187]
404211  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100000252  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
557176  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
394174  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
561737  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100002263  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
403000  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
768202  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a precursor [KO:K06276] [EC:2.7.11.1]
403146  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
560549  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
378972  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100149794  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101910198  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
30654  gsk3ba; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
557882  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
394155  gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
373082  gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
327301  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
407980  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
334597  ppp1cbl; protein phosphatase 1, catalytic subunit, beta isoform, like [KO:K06269] [EC:3.1.3.16]
100003223  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
571753  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
393807  ppp1r3cb; protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
436649  ppp1r3ca; protein phosphatase 1, regulatory subunit 3Ca [KO:K07189]
327285  ppp1r3b; protein phosphatase 1 regulatory subunit 3B [KO:K07189]
406459  ppp1r3c2b; Protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
567375  ppp1r3db; protein phosphatase 1, regulatory subunit 3Db [KO:K07189]
100001260  ppp1r3ab; protein phosphatase 1 regulatory subunit 3A [KO:K07189]
799144  ppp1r3da; protein phosphatase 1, regulatory subunit 3Da [KO:K07189]
571155  si:ch211-167b20.8; uncharacterized protein si:ch211-167b20.8 isoform X1 [KO:K07189]
101883751  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
565379  phkg1a; phosphorylase kinase, gamma 1a (muscle) [KO:K00871] [EC:2.7.11.19]
393937  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
554046  phkg1b; phosphorylase kinase, gamma 1b (muscle) [KO:K00871] [EC:2.7.11.19]
569706  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
556199  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X2 [KO:K07190]
572183  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
321808  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
192322  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
368217  calm1b; calmodulin-1b [KO:K02183]
406660  calm1a; calmodulin-1a [KO:K02183]
336121  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
327379  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
560151  calml4a; calmodulin-like protein 4a [KO:K02183]
100321746  calml4b; calmodulin-like protein 4 [KO:K02183]
403051  pygb; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
493916  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
553655  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
393444  pygmb; phosphorylase, glycogen, muscle b [KO:K00688] [EC:2.4.1.1]
563432  si:ch211-79e4.4; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
393998  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
445076  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
563147  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
564064  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
405894  prkar2ab; protein kinase, cAMP-dependent, regulatory, type II, alpha, B [KO:K04739]
556042  prkar2aa; protein kinase, cAMP-dependent, regulatory, type II, alpha A [KO:K04739]
767685  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit [KO:K04739]
550427  prkar1ab; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b [KO:K04739]
100331387  prkar2b; cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
494533  prkar1aa; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a [KO:K04739]
557893  lipeb; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
568368  lipea; lipase, hormone-sensitive a [KO:K07188] [EC:3.1.1.79]
555737  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
117507  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
393612  flot2b; flotillin-2b [KO:K07192]
245697  flot1b; flotillin-1b [KO:K07192]
245698  flot2a; flotillin-2a [KO:K07192]
561345  flot1a; flotillin-1a [KO:K07192]
100535524  sh2b2; SH2B adapter protein 2 [KO:K07193]
100002756  sorbs1; sorbin and SH3 domain-containing protein 1 isoform X5 [KO:K06086]
492364  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
556277  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
445234  crk; adapter molecule crk [KO:K04438]
556443  crkl; crk-like protein [KO:K04438]
394101  rapgef1b; rap guanine nucleotide exchange factor 1b [KO:K06277]
558635  rapgef1a; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
327510  rhoq; rho-related GTP-binding protein RhoQ [KO:K07194]
406723  exoc7; exocyst complex component 7 [KO:K07195]
492762  trip10a; cdc42-interacting protein 4 homolog [KO:K07196]
793274  srebf1; sterol regulatory element-binding protein 1 [KO:K07197]
559403  acaca; acetyl-CoA carboxylase 1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
556236  acacb; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
559001  fasn; fatty acid synthase isoform X1 [KO:K00665] [EC:2.3.1.85]
406339  hk2; hexokinase-2 [KO:K00844] [EC:2.7.1.1]
406791  hk1; hexokinase-1 [KO:K00844] [EC:2.7.1.1]
321224  hkdc1; hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
751668  gck; hexokinase-4 [KO:K12407] [EC:2.7.1.2]
572074  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100001198  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
335232  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
436905  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
100170795  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
406440  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
553319  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
678619  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
568316  prkag2b; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
570761  prkag2a; 5'-AMP-activated protein kinase subunit gamma-2a isoform 2 [KO:K07200]
567969  foxo1b; forkhead box protein O1-B [KO:K07201]
768121  foxo1a; forkhead box protein O1-A [KO:K07201]
553418  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3 [KO:K07202]
563180  g6pc1a.2; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
100000750  g6pc1b; Glucose-6-phosphatase b [KO:K01084] [EC:3.1.3.9]
445118  g6pc1a.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform 1 [KO:K01084] [EC:3.1.3.9]
790919  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
335231  fbp1a; fructose-1,6-bisphosphatase 1a [KO:K03841] [EC:3.1.3.11]
282672  fbp1b; fructose-1,6-bisphosphatase 1b [KO:K03841] [EC:3.1.3.11]
445505  fbp2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
378727  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
406473  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
324254  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
560455  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
562242  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
406349  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
445028  rps6; 40S ribosomal protein S6 [KO:K02991]
799566  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
79380  eif4ea; eukaryotic translation initiation factor 4E-1A [KO:K03259]
393732  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
541523  eif4e2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
550549  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
493617  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
30738  eif4e1b; eukaryotic translation initiation factor 4E-1B [KO:K03259]
337167  tsc1a; TSC complex subunit 1a [KO:K07206]
100330617  tsc1b; TSC complex subunit 1b [KO:K07206]
567524  tsc2; tuberin [KO:K07207]
393702  rheb; GTP-binding protein Rheb [KO:K07208]
767781  rhebl1; Ras homolog, mTORC1 binding like 1 [KO:K07208]
58100  badb; BCL2 associated agonist of cell death b isoform 1 [KO:K02158]
564921  bada; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
323818  shc1; SHC-transforming protein 1 isoform X3 [KO:K06279]
562011  shc2; SHC-transforming protein 2 [KO:K17447]
100332111  shc3; SHC-transforming protein 3 [KO:K17448]
406308  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
493609  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
561670  sos2; son of sevenless homolog 2 [KO:K03099]
556286  sos1; son of sevenless homolog 1 [KO:K03099]
553656  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
550286  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
445289  kras; GTPase KRas isoform 2 [KO:K07827]
393228  zgc:55558; GTPase KRas [KO:K07827]
30380  nras; GTPase NRas [KO:K07828]
403063  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
403065  braf; serine/threonine-protein kinase B-raf isoform 1 [KO:K04365] [EC:2.7.11.1]
30716  raf1a; Raf-1 proto-oncogene, serine/threonine kinase a [KO:K04366] [EC:2.7.11.1]
557109  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
406728  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
563181  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
100002225  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
360144  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399480  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
373121  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
334167  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a [KO:K04372] [EC:2.7.11.1]
555974  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
567895  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
445073  socs1a; suppressor of cytokine signaling 1a [KO:K04694]
100007521  socs1b; suppressor of cytokine signaling 1b [KO:K04694]
562062  socs2; suppressor of cytokine signaling 2 [KO:K04695]
406596  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
335409  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
797891  socs4; suppressor of cytokine signaling 4 [KO:K04697]
30081  ptpn1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
799867  ptprfb; receptor-type tyrosine-protein phosphatase F precursor [KO:K05695] [EC:3.1.3.48]
140819  ptprfa; protein tyrosine phosphatase receptor type Fa precursor [KO:K05695] [EC:3.1.3.48]
569698  mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
562720  mapk8a; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
65236  mapk8b; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
100149273  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
563560  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
325179  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
368433  inppl1b; inositol polyphosphate phosphatase-like 1b [KO:K15909] [EC:3.1.3.86]
101884388  inpp5a; type I inositol 1,4,5-trisphosphate 5-phosphatase [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
dre00010  Glycolysis / Gluconeogenesis
dre00061  Fatty acid biosynthesis
dre00500  Starch and sucrose metabolism
dre04010  MAPK signaling pathway
dre04070  Phosphatidylinositol signaling system
dre04210  Apoptosis
KO pathway
ko04910   
LinkDB

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