KEGG   PATHWAY: hsa00330
Entry
hsa00330                    Pathway                                
Name
Arginine and proline metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
Pathway map
hsa00330  Arginine and proline metabolism
hsa00330

Module
hsa_M00015  Proline biosynthesis, glutamate => proline [PATH:hsa00330]
hsa_M00047  Creatine pathway [PATH:hsa00330]
hsa_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:hsa00330]
hsa_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:hsa00330]
hsa_M00970  Proline degradation, proline => glutamate [PATH:hsa00330]
hsa_M00972  Proline metabolism [PATH:hsa00330]
Network
  Element
N01612  Creatine pathway
N01618  Proline biosynthesis, Orn to Pro
N01622  Proline degradation
N01623  Spermine biosynthesis
Drug
D00505  Phenelzine sulfate (USP)
D00826  Tranylcypromine sulfate (USP)
D00829  Eflornithine hydrochloride (USAN)
D01888  Safrazine hydrochloride (JAN)
D02559  Toloxatone (INN)
D02560  Brofaromine (INN)
D02561  Moclobemide (USAN/INN)
D02563  Befloxatone (INN)
D02579  Iproniazid (INN)
D02580  Isocarboxazid (INN)
D03248  Clorgiline (INN)
D03409  Caroxazone (USAN/INN)
D04793  Lufironil (USAN/INN)
D07258  Mitoguazone (INN)
D07337  Nialamide (INN)
D07338  Iproclozide (INN)
D07883  Eflornithine (INN)
D08085  Iproniazid phosphate
D08349  Phenelzine (BAN)
D08392  Pirlindole (INN)
D08393  Pirlindole hydrochloride
D08625  Tranylcypromine (INN)
D09018  Tilarginine acetate (USAN)
D11695  Pegzilarginase (USAN/INN)
Other DBs
GO: 0006525 0006560
Organism
Homo sapiens (human) [GN:hsa]
Gene
2628  GATM; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
2593  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
548596  CKMT1A; creatine kinase, mitochondrial 1A [KO:K00933] [EC:2.7.3.2]
1160  CKMT2; creatine kinase, mitochondrial 2 [KO:K00933] [EC:2.7.3.2]
1152  CKB; creatine kinase B [KO:K00933] [EC:2.7.3.2]
1159  CKMT1B; creatine kinase, mitochondrial 1B [KO:K00933] [EC:2.7.3.2]
1158  CKM; creatine kinase, M-type [KO:K27382] [EC:2.7.3.2]
113451  AZIN2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
4953  ODC1; ornithine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
6723  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
6611  SMS; spermine synthase [KO:K00802] [EC:2.5.1.22]
262  AMD1; adenosylmethionine decarboxylase 1 [KO:K01611] [EC:4.1.1.50]
26  AOC1; amine oxidase copper containing 1 [KO:K11182] [EC:1.4.3.22]
54498  SMOX; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
84735  CNDP1; carnosine dipeptidase 1 [KO:K05604] [EC:3.4.13.20]
55748  CNDP2; carnosine dipeptidase 2 [KO:K08660] [EC:3.4.13.18]
57571  CARNS1; carnosine synthase 1 [KO:K14755] [EC:6.3.2.11]
112483  SAT2; spermidine/spermine N1-acetyltransferase family member 2 [KO:K00657] [EC:2.3.1.57]
6303  SAT1; spermidine/spermine N1-acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
79814  AGMAT; agmatinase (putative) [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
4842  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
4843  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
4846  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
384  ARG2; arginase 2 [KO:K01476] [EC:3.5.3.1]
383  ARG1; arginase 1 [KO:K01476] [EC:3.5.3.1]
4942  OAT; ornithine aminotransferase [KO:K00819] [EC:2.6.1.13]
65263  PYCR3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
29920  PYCR2; pyrroline-5-carboxylate reductase 2 [KO:K00286] [EC:1.5.1.2]
5831  PYCR1; pyrroline-5-carboxylate reductase 1 [KO:K00286] [EC:1.5.1.2]
5625  PRODH; proline dehydrogenase 1 [KO:K00318] [EC:1.5.5.2]
8659  ALDH4A1; aldehyde dehydrogenase 4 family member A1 [KO:K00294] [EC:1.2.1.88]
5832  ALDH18A1; aldehyde dehydrogenase 18 family member A1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
51056  LAP3; leucine aminopeptidase 3 [KO:K11142] [EC:3.4.11.1 3.4.11.5]
8974  P4HA2; prolyl 4-hydroxylase subunit alpha 2 [KO:K00472] [EC:1.14.11.2]
283208  P4HA3; prolyl 4-hydroxylase subunit alpha 3 [KO:K00472] [EC:1.14.11.2]
5033  P4HA1; prolyl 4-hydroxylase subunit alpha 1 [KO:K00472] [EC:1.14.11.2]
58510  PRODH2; proline dehydrogenase 2 [KO:K11394] [EC:1.5.5.3]
2805  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
137362  GOT1L1; glutamic-oxaloacetic transaminase 1 like 1 [KO:K14454] [EC:2.6.1.1]
2806  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
112817  HOGA1; 4-hydroxy-2-oxoglutarate aldolase 1 [KO:K18123] [EC:4.1.3.16]
1610  DAO; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
112849  L3HYPDH; trans-L-3-hydroxyproline dehydratase [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00220  Arginine biosynthesis
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00260  Glycine, serine and threonine metabolism
hsa00270  Cysteine and methionine metabolism
hsa00310  Lysine degradation
hsa00410  beta-Alanine metabolism
hsa00470  D-Amino acid metabolism
hsa00480  Glutathione metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00650  Butanoate metabolism
hsa00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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