KEGG   PATHWAY: ko00062
Entry
ko00062                     Pathway                                
Name
Fatty acid elongation
Class
Metabolism; Lipid metabolism
Pathway map
ko00062  Fatty acid elongation
ko00062

Module
M00085  Fatty acid elongation in mitochondria [PATH:ko00062]
M00415  Fatty acid elongation in endoplasmic reticulum [PATH:ko00062]
Other DBs
GO: 0030497
Orthology
K07508  acetyl-CoA acyltransferase 2 [EC:2.3.1.16]
K07509  acetyl-CoA acyltransferase [EC:2.3.1.16]
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07512  mitochondrial enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase [EC:1.3.1.- 1.3.1.38]
K01074  palmitoyl-protein thioesterase [EC:3.1.2.22]
K10247  elongation of very long chain fatty acids protein 1 [EC:2.3.1.199]
K10205  elongation of very long chain fatty acids protein 2 [EC:2.3.1.199]
K10248  elongation of very long chain fatty acids protein 3 [EC:2.3.1.199]
K10249  elongation of very long chain fatty acids protein 4 [EC:2.3.1.199]
K10244  elongation of very long chain fatty acids protein 5 [EC:2.3.1.199]
K10203  elongation of very long chain fatty acids protein 6 [EC:2.3.1.199]
K10250  elongation of very long chain fatty acids protein 7 [EC:2.3.1.199]
K15397  3-ketoacyl-CoA synthase [EC:2.3.1.199]
K10245  fatty acid elongase 2 [EC:2.3.1.199]
K10246  fatty acid elongase 3 [EC:2.3.1.199]
K10251  17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
K10703  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]
K10258  very-long-chain enoyl-CoA reductase [EC:1.3.1.93]
K01068  acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
K17360  acyl-coenzyme A thioesterase 7 [EC:3.1.2.2]
K16339  acyl-coenzyme A thioesterase THEM4 [EC:3.1.2.2]
K22554  acyl-coenzyme A thioesterase THEM5 [EC:3.1.2.2]
Compound
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00083  Malonyl-CoA
C00136  Butanoyl-CoA
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00249  Hexadecanoic acid
C00264  3-Oxoacyl-CoA
C00605  2,3-Dehydroacyl-CoA
C00638  Long-chain fatty acid
C00640  (3S)-3-Hydroxyacyl-CoA
C00658  trans-2,3-Dehydroacyl-CoA
C01832  Lauroyl-CoA
C01944  Octanoyl-CoA
C02593  Tetradecanoyl-CoA
C02843  Long-chain acyl-CoA
C03221  2-trans-Dodecenoyl-CoA
C05258  (S)-3-Hydroxyhexadecanoyl-CoA
C05259  3-Oxopalmitoyl-CoA
C05260  (S)-3-Hydroxytetradecanoyl-CoA
C05261  3-Oxotetradecanoyl-CoA
C05262  (S)-3-Hydroxydodecanoyl-CoA
C05263  3-Oxododecanoyl-CoA
C05264  (S)-Hydroxydecanoyl-CoA
C05265  3-Oxodecanoyl-CoA
C05266  (S)-3-Hydroxyoctanoyl-CoA
C05267  3-Oxooctanoyl-CoA
C05268  (S)-Hydroxyhexanoyl-CoA
C05269  3-Oxohexanoyl-CoA
C05270  Hexanoyl-CoA
C05271  trans-Hex-2-enoyl-CoA
C05272  trans-Hexadec-2-enoyl-CoA
C05273  trans-Tetradec-2-enoyl-CoA
C05274  Decanoyl-CoA
C05275  trans-Dec-2-enoyl-CoA
C05276  trans-Oct-2-enoyl-CoA
C20876  Very-long-chain acyl-CoA
C20877  Very-long-chain 3-oxoacyl-CoA
C20878  Very-long-chain (3R)-3-hydroxyacyl-CoA
C20879  Very-long-chain trans-2,3-dehydroacyl-CoA
Reference
PMID:4387390
  Authors
Seubert W, Lamberts I, Kramer R, Ohly B
  Title
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA.
  Journal
Biochim Biophys Acta 164:498-517 (1968)
DOI:10.1016/0005-2760(68)90180-X
Reference
PMID:7150615
  Authors
El-Fakhri M, Middleton B
  Title
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.
  Journal
Biochim Biophys Acta 713:270-9 (1982)
DOI:10.1016/0005-2760(82)90244-2
Reference
PMID:8190743
  Authors
Cassagne C, Lessire R, Bessoule JJ, Moreau P, Creach A, Schneider F, Sturbois B
  Title
Biosynthesis of very long chain fatty acids in higher plants.
  Journal
Prog Lipid Res 33:55-69 (1994)
DOI:10.1016/0163-7827(94)90009-4
Reference
PMID:16564093
  Authors
Jakobsson A, Westerberg R, Jacobsson A.
  Title
Fatty acid elongases in mammals: their regulation and roles in metabolism.
  Journal
Prog Lipid Res 45:237-49 (2006)
DOI:10.1016/j.plipres.2006.01.004
Reference
PMID:16765910
  Authors
Blacklock BJ, Jaworski JG
  Title
Substrate specificity of Arabidopsis 3-ketoacyl-CoA synthases.
  Journal
Biochem Biophys Res Commun 346:583-90 (2006)
DOI:10.1016/j.bbrc.2006.05.162
Reference
PMID:16866954
  Authors
Shepherd T, Wynne Griffiths D
  Title
The effects of stress on plant cuticular waxes.
  Journal
New Phytol 171:469-99 (2006)
DOI:10.1111/j.1469-8137.2006.01826.x
Reference
PMID:17719534
  Authors
Riezman H
  Title
The long and short of fatty acid synthesis.
  Journal
Cell 130:587-8 (2007)
DOI:10.1016/j.cell.2007.08.008
Reference
PMID:19649180
  Authors
Raffaele S, Leger A, Roby D
  Title
Very long chain fatty acid and lipid signaling in the response of plants to pathogens.
  Journal
Plant Signal Behav 4:94-9 (2009)
DOI:10.4161/psb.4.2.7580
Related
pathway
ko00071  Fatty acid degradation
ko00073  Cutin, suberine and wax biosynthesis
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