KEGG   PATHWAY: ko03440
Entry
ko03440                     Pathway                                
Name
Homologous recombination
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ko03440  Homologous recombination
ko03440

Other DBs
GO: 0000724
Orthology
K07462  single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
K03111  single-strand DNA-binding protein
K03629  DNA replication and repair protein RecF
K03584  DNA repair protein RecO (recombination protein O)
K06187  recombination protein RecR
K03553  recombination protein RecA
K02335  DNA polymerase I [EC:2.7.7.7]
K03550  holliday junction DNA helicase RuvA
K03551  holliday junction DNA helicase RuvB [EC:5.6.2.4]
K01159  crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
K03655  ATP-dependent DNA helicase RecG [EC:5.6.2.4]
K03582  exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
K03583  exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
K03581  exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
K02337  DNA polymerase III subunit alpha [EC:2.7.7.7]
K03763  DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
K02338  DNA polymerase III subunit beta [EC:2.7.7.7]
K02343  DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
K02340  DNA polymerase III subunit delta [EC:2.7.7.7]
K02341  DNA polymerase III subunit delta' [EC:2.7.7.7]
K02342  DNA polymerase III subunit epsilon [EC:2.7.7.7]
K14159  ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7]
K02345  DNA polymerase III subunit theta [EC:2.7.7.7]
K02339  DNA polymerase III subunit chi [EC:2.7.7.7]
K02344  DNA polymerase III subunit psi [EC:2.7.7.7]
K04066  primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
K02686  primosomal replication protein N
K04067  primosomal replication protein N''
K02317  DNA replication protein DnaT
K10866  DNA repair protein RAD50 [EC:3.6.-.-]
K10865  double-strand break repair protein MRE11
K10868  DNA repair protein XRS2
K10867  nibrin
K04728  serine-protein kinase ATM [EC:2.7.11.1]
K10605  breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K10683  BRCA1-associated RING domain protein 1
K20773  DNA endonuclease RBBP8 [EC:3.1.-.-]
K15362  fanconi anemia group J protein [EC:5.6.2.3]
K10728  topoisomerase (DNA) II binding protein 1
K20774  BRCA1-A complex subunit Abraxas
K20775  BRCA1-A complex subunit RAP80
K20776  BRISC and BRCA1-A complex member 1
K12173  BRCA1-A complex subunit BRE
K11864  BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
K10897  partner and localizer of BRCA2
K08775  breast cancer 2 susceptibility protein
K10881  26 proteasome complex subunit DSS1
K19528  synaptonemal complex protein 3
K10957  DNA repair protein RAD55
K10958  DNA repair protein RAD57
K07466  replication factor A1
K10739  replication factor A2
K10740  replication factor A3
K10741  replication factor A4
K04482  DNA repair protein RAD51
K10873  DNA repair and recombination protein RAD52
K10869  RAD51-like protein 1
K10870  RAD51-like protein 2
K10871  RAD51-like protein 3
K10879  DNA-repair protein XRCC2
K10880  DNA-repair protein XRCC3
K10959  DNA repair protein RAD59
K10875  DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
K10877  DNA repair and recombination protein RAD54B [EC:5.6.2.-]
K02327  DNA polymerase delta subunit 1 [EC:2.7.7.7]
K02328  DNA polymerase delta subunit 2
K03504  DNA polymerase delta subunit 3
K03505  DNA polymerase delta subunit 4
K10901  bloom syndrome protein [EC:5.6.2.4]
K03165  DNA topoisomerase III [EC:5.6.2.1]
K08991  crossover junction endonuclease MUS81 [EC:3.1.22.-]
K10882  crossover junction endonuclease EME1 [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
LinkDB

DBGET integrated database retrieval system