Entry
Name
MAPK signaling pathway - yeast
Description
The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MAPKK/MEK), which is itself phosphorylated by a MEK kinase (MAPKKK/MEKK).
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
ko04011 MAPK signaling pathway - yeast
Ortholog table
Other DBs
Orthology
K11234 mating pheromone alpha-factor
K11235 mating pheromone A-factor
K11213 pheromone alpha factor receptor
K04627 pheromone a factor receptor
K19860 guanine nucleotide-binding protein alpha-1 subunit
K04536 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K07973 guanine nucleotide-binding protein subunit gamma, fungi
K19838 GTPase-activating protein SST2
K11236 cell division control protein 24
K04393 cell division control protein 42
K19839 Rho-type GTPase-activating protein 1/2
K19840 Rho-type GTPase-activating protein
K11237 bud emergence protein 1
K11239 pheromone-response scaffold protein
K11215 transcription factor STE12
K11241 down-regulator of invasive growth 1
K11242 down-regulator of invasive growth 2
K12412 pheromone receptor transcription factor
K06652 cyclin-dependent kinase inhibitor FAR1
K12760 G1/S-specific cyclin CLN1
K06650 G1/S-specific cyclin CLN2
K11244 cell wall integrity and stress response component
K11245 mating pheromone-induced death protein 2
K19842 RHO1 GDP-GTP exchange protein 1/2
K19843 Rho1 guanine nucleotide exchange factor TUS1
K04513 Ras homolog gene family, member A
K19844 GTPase-activating protein BEM2
K19845 GTPase-activating protein SAC7
K09265 transcription factor RLM1
K15174 RNA polymerase II-associated factor 1
K06649 regulatory protein SWI4
K06648 regulatory protein SWI6
K02220 G2/mitotic-specific cyclin 1
K23469 G2/mitotic-specific cyclin 2
K11231 osomolarity two-component system, sensor histidine kinase SLN1 [EC:2.7.13.3 ]
K11232 osomolarity two-component system, phosphorelay intermediate protein YPD1
K11233 osomolarity two-component system, response regulator SSK1
K19815 high-osmolarity-induced transcription protein 1
K19807 transcription factor SMP1
K09468 zinc finger protein MSN2/4
K09051 ATF/CREB family transcription factor
K06665 general transcriptional corepressor CYC8
K06666 general transcriptional corepressor TUP1
K03085 substrate and inhibitor of the cyclin-dependent protein kinase CDC28
K06651 S-phase entry cyclin 5/6
K02515 serine/threonine-protein kinase HSL1, negative regulator of Swe1 kinase [EC:2.7.11.-]
K19816 transcription activator MSS11
K09448 transcriptional enhancer factor
K19851 flocculation protein FLO11
Reference
Authors
Bardwell L
Title
A walk-through of the yeast mating pheromone response pathway.
Journal
Reference
Authors
Levin DE
Title
Cell wall integrity signaling in Saccharomyces cerevisiae.
Journal
Reference
Authors
Levin DE
Title
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
Journal
Reference
Authors
Hohmann S, Krantz M, Nordlander B
Title
Yeast osmoregulation.
Journal
Reference
Authors
Saito H, Posas F
Title
Response to hyperosmotic stress.
Journal
Reference
Authors
Cullen PJ, Sprague GF Jr
Title
The regulation of filamentous growth in yeast.
Journal
Reference
Authors
Gustin MC, Albertyn J, Alexander M, Davenport K
Title
MAP kinase pathways in the yeast Saccharomyces cerevisiae.
Journal
Microbiol Mol Biol Rev 62:1264-300 (1998)
Reference
Authors
Chen RE, Thorner J
Title
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
Journal
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