Entry Name mTOR signaling pathway
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Orthology K13780 solute carrier family 7 (L-type amino acid transporter), member 5
K06519 solute carrier family 3, member 2
K14995 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9
K02147 V-type H+-transporting ATPase subunit B
K02148 V-type H+-transporting ATPase subunit C
K02149 V-type H+-transporting ATPase subunit D
K02150 V-type H+-transporting ATPase subunit E
K02151 V-type H+-transporting ATPase subunit F
K02152 V-type H+-transporting ATPase subunit G
K02144 V-type H+-transporting ATPase subunit H
K20397 ragulator complex protein LAMTOR1
K20398 ragulator complex protein LAMTOR2
K04370 ragulator complex protein LAMTOR3
K20399 ragulator complex protein LAMTOR4
K16344 ragulator complex protein LAMTOR5
K20400 folliculin-interacting protein 1
K20401 folliculin-interacting protein 2
K16185 Ras-related GTP-binding protein A/B
K16186 Ras-related GTP-binding protein C/D
K23080 cytosolic arginine sensor for mTORC1 subunit 1
K23081 cytosolic arginine sensor for mTORC1 subunit 2
K20407 SEA/GATOR complex protein SEA4/MIOS
K20408 SEA/GATOR complex protein SEA2/WDR24
K20409 SEA/GATOR complex protein SEA3/WDR59
K14004 protein transport protein SEC13
K20404 SEA/GATOR complex protein SEA1/DEPDC5
K20405 nitrogen permease regulator 2
K20406 nitrogen permease regulator 3
K03875 F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K07204 regulatory associated protein of mTOR
K16184 proline-rich AKT1 substrate 1
K20402 DEP domain-containing mTOR-interacting protein
K08266 target of rapamycin complex subunit LST8
K11137 telomere length regulation protein
K20403 TELO2-interacting protein 1
K10421 CAP-Gly domain-containing linker protein 1
K20064 growth factor receptor-bound protein 10
K07205 eukaryotic translation initiation factor 4E binding protein 1
K03259 translation initiation factor 4E
K03258 translation initiation factor 4B
K02991 small subunit ribosomal protein S6e
K08271 STE20-related kinase adapter protein alpha
K17532 STE20-related kinase adapter protein beta
K08272 calcium binding protein 39
K07198 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31 ]
K20396 TBC1 domain family member 7
K07208 Ras homolog enriched in brain
K08270 DNA-damage-inducible transcript 4
K03209 wingless-type MMTV integration site family, member 1
K00182 wingless-type MMTV integration site family, member 2
K00312 wingless-type MMTV integration site family, member 3
K00408 wingless-type MMTV integration site family, member 4
K00444 wingless-type MMTV integration site family, member 5
K00445 wingless-type MMTV integration site family, member 6
K00572 wingless-type MMTV integration site family, member 7
K00714 wingless-type MMTV integration site family, member 8
K01064 wingless-type MMTV integration site family, member 9
K01357 wingless-type MMTV integration site family, member 10
K01384 wingless-type MMTV integration site family, member 11
K01558 wingless-type MMTV integration site family, member 16
K03068 low density lipoprotein receptor-related protein 5/6
K02353 segment polarity protein dishevelled
K03156 tumor necrosis factor superfamily, member 2
K03158 tumor necrosis factor receptor superfamily member 1A
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K05459 insulin-like growth factor 1
K04364 growth factor receptor-bound protein 2
K04365 B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K16172 insulin receptor substrate 1
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K20410 target of rapamycin complex 2 subunit MAPKAP1/AVO1
K08267 rapamycin-insensitive companion of mTOR
K04513 Ras homolog gene family, member A
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related ko04810 Regulation of actin cytoskeleton
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