Entry
Name
Cellular senescence
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Orthology
K13375 transforming growth factor beta-1
K13376 transforming growth factor beta-2
K13377 transforming growth factor beta-3
K04500 mothers against decapentaplegic homolog 2
K23605 mothers against decapentaplegic homolog 3
K04685 cyclin-dependent kinase inhibitor 2B
K04503 G1/S-specific cyclin-D1
K10151 G1/S-specific cyclin-D2
K10152 G1/S-specific cyclin-D3
K06618 retinoblastoma-associated protein
K04681 retinoblastoma-like protein 1
K16332 retinoblastoma-like protein 2
K17454 transcription factor E2F1
K09389 transcription factor E2F2
K06620 transcription factor E2F3
K04682 transcription factor E2F4/5
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K07201 forkhead box protein O1
K09408 forkhead box protein O3
K06625 cyclin-dependent kinase inhibitor 1A
K06626 G1/S-specific cyclin-E1
K24231 killer cell immunoglobulin-like receptor 2DL4
K07829 Ras-related protein R-Ras
K07830 Ras-related protein R-Ras2
K07831 Ras-related protein M-Ras
K07208 Ras homolog enriched in brain
K10752 histone-binding protein RBBP4
K04377 Myc proto-oncogene protein
K06621 cyclin-dependent kinase inhibitor 2A
K08015 Ras association domain-containing protein 5
K03362 F-box and WD-40 domain protein 1/11
K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16 ]
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04402 growth arrest and DNA-damage-inducible protein
K05868 G2/mitotic-specific cyclin-B1
K21770 G2/mitotic-specific cyclin-B2
K21771 G2/mitotic-specific cyclin-B3
K10865 double-strand break repair protein MRE11
K10866 DNA repair protein RAD50 [EC:3.6.-.-]
K10995 cell cycle checkpoint control protein RAD9B
K10903 HUS1 checkpoint protein
K02580 nuclear factor NF-kappa-B p105 subunit
K04735 transcription factor p65
K10138 insulin-like growth factor-binding protein 3
K03982 plasminogen activator inhibitor 1
K07205 eukaryotic translation initiation factor 4E binding protein 1
K04443 mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1 ]
K18753 butyrate response factor
K04851 voltage-dependent calcium channel L type alpha-1D
K04973 transient receptor potential cation channel subfamily V member 4
K04982 transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1 ]
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16 ]
K06268 serine/threonine-protein phosphatase 2B regulatory subunit
K04446 nuclear factor of activated T-cells, cytoplasmic 1
K17332 nuclear factor of activated T-cells, cytoplasmic 2
K17333 nuclear factor of activated T-cells, cytoplasmic 3
K17334 nuclear factor of activated T-cells, cytoplasmic 4
K04958 inositol 1,4,5-triphosphate receptor type 1
K04959 inositol 1,4,5-triphosphate receptor type 2
K04960 inositol 1,4,5-triphosphate receptor type 3
K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K05862 voltage-dependent anion channel protein 1
K15040 voltage-dependent anion channel protein 2
K15041 voltage-dependent anion channel protein 3
K20858 calcium uniporter protein, mitochondrial
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Munoz-Espin D, Serrano M
Title
Cellular senescence: from physiology to pathology.
Journal
Reference
Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Journal
Reference
Authors
Sharpless NE, Sherr CJ
Title
Forging a signature of in vivo senescence.
Journal
Reference
Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
Title
Senescence as a general cellular response to stress: A mini-review.
Journal
Reference
Authors
Lujambio A
Title
To clear, or not to clear (senescent cells)? That is the question.
Journal
Reference
Authors
Di Mitri D, Alimonti A
Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
Journal
Reference
Authors
Francica P, Aebersold DM, Medova M
Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
Journal
Reference
Authors
Bartling B
Title
Cellular senescence in normal and premature lung aging.
Journal
Reference
Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
Title
Programmed cell senescence during mammalian embryonic development.
Journal
Reference
Authors
Herranz N, Gallage S, Gil J
Title
TORn about SASP regulation.
Journal
Reference
Authors
Martin N, Bernard D
Title
Calcium signaling and cellular senescence.
Journal
Reference
Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
Title
Calcium homeostasis in cancer: A focus on senescence.
Journal
Reference
Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
Journal
Reference
Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
Title
Ras signaling through RASSF proteins.
Journal
Reference
Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
Journal
Reference
Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Journal
Reference
Authors
Cao X, Li M
Title
A New Pathway for Senescence Regulation.
Journal
Reference
Authors
Gire V, Dulic V
Title
Senescence from G2 arrest, revisited.
Journal
Reference
Authors
Mowla SN, Lam EW, Jat PS
Title
Cellular senescence and aging: the role of B-MYB.
Journal
Reference
Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
Journal
Reference
Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
Journal
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