Entry
Name
Axon guidance
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Orthology
K06765 deleted in colorectal carcinoma
K04964 transient receptor potential cation channel subfamily C member 1
K04966 transient receptor potential cation channel subfamily C member 3
K04967 transient receptor potential cation channel subfamily C member 4
K04968 transient receptor potential cation channel subfamily C member 5
K04969 transient receptor potential cation channel subfamily C member 6
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16 ]
K06268 serine/threonine-protein phosphatase 2B regulatory subunit
K17332 nuclear factor of activated T-cells, cytoplasmic 2
K17333 nuclear factor of activated T-cells, cytoplasmic 3
K17334 nuclear factor of activated T-cells, cytoplasmic 4
K04392 Ras-related C3 botulinum toxin substrate 1
K07860 Ras-related C3 botulinum toxin substrate 2
K07861 Ras-related C3 botulinum toxin substrate 3
K04393 cell division control protein 42
K07520 actin-binding LIM protein
K04513 Ras homolog gene family, member A
K07293 tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48 ]
K23096 repulsive guidance molecule A
K12753 myosin regulatory light chain 5
K12755 myosin regulatory light chain 9
K12757 myosin regulatory light chain 12
K07532 Rho guanine nucleotide exchange factor 12
K24609 leucine-rich repeats and immunoglobulin-like domains protein 2
K04352 Ras GTPase-activating protein 1
K07525 neuronal guanine nucleotide exchange factor
K07524 regulator of G-protein signalling 3
K10031 C-X-C motif chemokine 12
K04189 C-X-C chemokine receptor type 4
K04630 guanine nucleotide-binding protein G(i) subunit alpha
K06753 roundabout, axon guidance receptor 1
K06754 roundabout, axon guidance receptor 2
K06755 roundabout, axon guidance receptor 3
K07526 SLIT-ROBO Rho GTPase activating protein
K06550 L1 cell adhesion molecule
K07530 Ras homolog gene family, member D
K07529 dihydropyrimidinase-like 5
K07528 dihydropyrimidinase-like 2
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K07829 Ras-related protein R-Ras
K00444 wingless-type MMTV integration site family, member 5
K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17 ]
K00408 wingless-type MMTV integration site family, member 4
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04237 partitioning defective protein 3
K06093 partitioning defective protein 6
K16621 bone morphogenetic protein 7
K20013 growth differentiation factor 7
Compound
Reference
Authors
Guan KL, Rao Y.
Title
Signalling mechanisms mediating neuronal responses to guidance cues.
Journal
Reference
Authors
Govek EE, Newey SE, Van Aelst L.
Title
The role of the Rho GTPases in neuronal development.
Journal
Reference
Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal
Reference
Authors
Negishi M, Oinuma I, Katoh H.
Title
Plexins: axon guidance and signal transduction.
Journal
Reference
Authors
Huot J.
Title
Ephrin signaling in axon guidance.
Journal
Reference
Authors
Patel BN, Van Vactor DL.
Title
Axon guidance: the cytoplasmic tail.
Journal
Reference
Authors
Yu TW, Bargmann CI.
Title
Dynamic regulation of axon guidance.
Journal
Reference
Authors
Dickson BJ.
Title
Molecular mechanisms of axon guidance.
Journal
Reference
Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal
Reference
Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal
Reference
Authors
Fujita Y, Yamashita T
Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal
Reference
Authors
Yamashita T, Mueller BK, Hata K
Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal
Reference
Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal
Related pathway
ko04060 Cytokine-cytokine receptor interaction
ko04810 Regulation of actin cytoskeleton
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