Entry Name Tight junction
Description Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class Cellular Processes; Cellular community - eukaryotesBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K06089 junctional adhesion molecule 1
K06735 junctional adhesion molecule 2
K06785 junctional adhesion molecule 3
K21108 blood vessel epicardial substance
K04393 cell division control protein 42
K06093 partitioning defective protein 6
K06091 MAGUK p55 subfamily member 5
K21109 MAGUK p55 subfamily member 4
K06097 tight junction protein 3
K06095 multiple PDZ domain protein
K20638 Rho GTPase-activating protein 17
K04392 Ras-related C3 botulinum toxin substrate 1
K06094 lethal(2) giant larvae protein
K04382 serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16 ]
K03456 serine/threonine-protein phosphatase 2A regulatory subunit A
K04354 serine/threonine-protein phosphatase 2A regulatory subunit B
K04237 partitioning defective protein 3
K05731 T-lymphoma invasion and metastasis-inducing protein 1
K05701 tight junction protein 1
K06105 tight junction protein 4
K21110 cingulin-like protein 1
K12791 Rho guanine nucleotide exchange factor 2
K04513 Ras homolog gene family, member A
K21099 MARVEL domain-containing protein 3
K04440 mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04448 transcription factor AP-1
K06448 T-cell surface glycoprotein CD1
K05031 cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6 ]
K06099 cold shock domain protein A
K04802 proliferating cell nuclear antigen
K04503 G1/S-specific cyclin-D1
K08367 runt-related transcription factor 1
K09489 heat shock 70kDa protein 4
K13365 sodium/hydrogen exchange regulatory cofactor NHE-RF1
K04851 voltage-dependent calcium channel L type alpha-1D
K17260 actin-related protein 2
K18584 actin-related protein 3
K05757 actin related protein 2/3 complex, subunit 1A/1B
K05758 actin related protein 2/3 complex, subunit 2
K05756 actin related protein 2/3 complex, subunit 3
K05755 actin related protein 2/3 complex, subunit 4
K05754 actin related protein 2/3 complex, subunit 5
K20479 WASP homolog-associated protein with actin, membranes and microtubules
K05747 Wiskott-Aldrich syndrome protein
K06274 vasodilator-stimulated phosphoprotein
K06109 Ras-related protein Rab-13
K21066 A-kinase anchor protein 18
K10351 myosin regulatory light chain 2
K21111 band 4.1-like protein 4B
K07198 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31 ]
K07199 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 5'-AMP-activated protein kinase, regulatory gamma subunit
K10352 myosin heavy chain 9/10/11/14
K12755 myosin regulatory light chain 9
K12757 myosin regulatory light chain 12
K06786 junctional adhesion molecule 4
K05631 atrophin-1 interacting protein 3 (BAI1-associated protein 1)
K07901 Ras-related protein Rab-8A
K07902 Ras-related protein Rab-8B
K08020 Rap guanine nucleotide exchange factor 6
K04353 Ras-related protein Rap-1A
K06098 tight junction protein 2
K08018 Rap guanine nucleotide exchange factor 2
K07839 Ras-related protein Rap-2C
K17291 MARVEL domain-containing protein 2
Compound Reference Authors Zihni C, Mills C, Matter K, Balda MS
Title Tight junctions: from simple barriers to multifunctional molecular gates.
Journal Reference Authors Martin-Belmonte F, Perez-Moreno M
Title Epithelial cell polarity, stem cells and cancer.
Journal Reference Authors Weber C, Fraemohs L, Dejana E
Title The role of junctional adhesion molecules in vascular inflammation.
Journal Reference Authors Miyoshi J, Takai Y
Title Molecular perspective on tight-junction assembly and epithelial polarity.
Journal Reference Authors Mertens AE, Pegtel DM, Collard JG
Title Tiam1 takes PARt in cell polarity.
Journal Reference Authors Shin K, Fogg VC, Margolis B
Title Tight junctions and cell polarity.
Journal Reference Authors Kooistra MR, Dube N, Bos JL
Title Rap1: a key regulator in cell-cell junction formation.
Journal Reference Authors Gonzalez-Mariscal L, Tapia R, Chamorro D
Title Crosstalk of tight junction components with signaling pathways.
Journal Reference Authors Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
Title Polarity complex proteins.
Journal Reference Authors Iden S, Collard JG
Title Crosstalk between small GTPases and polarity proteins in cell polarization.
Journal Reference Authors Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
Title PKC and the control of localized signal dynamics.
Journal Reference Authors Terry S, Nie M, Matter K, Balda MS
Title Rho signaling and tight junction functions.
Journal Reference Authors Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
Title Bves modulates tight junction associated signaling.
Journal Reference Authors Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
Title Regulation of small GTPases at epithelial cell-cell junctions.
Journal Reference Authors Lickert H, Van Campenhout CA
Title Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
Journal Reference Authors Spadaro D, Tapia R, Pulimeno P, Citi S
Title The control of gene expression and cell proliferation by the epithelial apical junctional complex.
Journal Reference Authors Moleirinho S, Guerrant W, Kissil JL
Title The Angiomotins--from discovery to function.
Journal Reference Authors Rodriguez-Boulan E, Macara IG
Title Organization and execution of the epithelial polarity programme.
Journal Reference Authors Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
Title Tight junctions and the regulation of gene expression.
Journal Reference Authors Mack NA, Georgiou M
Title The interdependence of the Rho GTPases and apicobasal cell polarity.
Journal Reference Authors Citi S, Guerrera D, Spadaro D, Shah J
Title Epithelial junctions and Rho family GTPases: the zonular signalosome.
Journal Reference Authors Zihni C, Terry SJ
Title RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
Journal Reference Authors Nakano A, Takashima S
Title LKB1 and AMP-activated protein kinase: regulators of cell polarity.
Journal Reference Authors Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
Title Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
Journal Reference Authors Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
Title The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
Journal Reference Authors Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
Title JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
Journal Related ko04810 Regulation of actin cytoskeleton
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