Entry Name Platelet activation
Description Platelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by adhesion to adhesive macromolecules, such as collagen and von Willebrand factor (vWF), or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2. Different receptors are stimulated by various agonists, almost converging in increasing intracellular Ca2+ concentration that stimulate platelet shape change and granule secretion and ultimately induce the "inside-out" signaling process leading to activation of the ligand-binding function of integrin alpha IIb beta 3. Binding of alpha IIb beta 3 to its ligands, mainly fibrinogen, mediates platelet adhesion and aggregation and triggers "outside-in" signaling, resulting in platelet spreading, additional granule secretion, stabilization of platelet adhesion and aggregation, and clot retraction.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K04264 thromboxane A2 receptor
K03914 coagulation factor II (thrombin) receptor
K04236 coagulation factor II (thrombin) receptor-like 3
K04639 guanine nucleotide-binding protein subunit alpha-13
K12330 Rho guanine nucleotide exchange factor 1
K07532 Rho guanine nucleotide exchange factor 12
K04513 Ras homolog gene family, member A
K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16 ]
K06270 protein phosphatase 1 regulatory subunit 12A
K12757 myosin regulatory light chain 12
K16056 calcium release-activated calcium channel protein 1
K04958 inositol 1,4,5-triphosphate receptor type 1
K04959 inositol 1,4,5-triphosphate receptor type 2
K04960 inositol 1,4,5-triphosphate receptor type 3
K16059 stromal interaction molecule 1
K04634 guanine nucleotide-binding protein G(q) subunit alpha
K04350 RAS guanyl-releasing protein 1
K12361 RAS guanyl-releasing protein 2
K04353 Ras-related protein Rap-1A
K07836 Ras-related protein Rap-1B
K17704 amyloid beta A4 precursor protein-binding family B member 1-interacting protein
K04630 guanine nucleotide-binding protein G(i) subunit alpha
K04632 guanine nucleotide-binding protein G(s) subunit alpha
K21289 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153 ]
K21290 phosphoinositide-3-kinase regulatory subunit 5/6
K06274 vasodilator-stimulated phosphoprotein
K05732 glucocorticoid receptor DNA-binding factor 1
K06472 low affinity immunoglobulin gamma Fc receptor II-a
K19720 collagen type III alpha
K06264 platelet glycoprotein VI
K07983 high affinity immunoglobulin epsilon receptor subunit gamma
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K07361 lymphocyte cytosolic protein 2
K06260 platelet glycoprotein V
K06261 platelet glycoprotein Ib alpha chain
K06262 platelet glycoprotein Ib beta chain
K06263 platelet glycoprotein IX
K08508 synaptosomal-associated protein 23
K08512 vesicle-associated membrane protein 8
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Li Z, Delaney MK, O'Brien KA, Du X
Title Signaling during platelet adhesion and activation.
Journal Reference Authors Broos K, De Meyer SF, Feys HB, Vanhoorelbeke K, Deckmyn H
Title Blood platelet biochemistry.
Journal Reference Authors Jurk K, Kehrel BE
Title Platelets: physiology and biochemistry.
Journal Reference Authors Offermanns S
Title Activation of platelet function through G protein-coupled receptors.
Journal Reference Authors Varga-Szabo D, Pleines I, Nieswandt B
Title Cell adhesion mechanisms in platelets.
Journal Reference Authors Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X
Title Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
Journal Reference Authors Bergmeier W, Stefanini L
Title Novel molecules in calcium signaling in platelets.
Journal Reference Authors Cifuni SM, Wagner DD, Bergmeier W
Title CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
Journal Reference Authors Heemskerk JW, Mattheij NJ, Cosemans JM
Title Platelet-based coagulation: different populations, different functions.
Journal Reference Authors Rivera J, Lozano ML, Navarro-Nunez L, Vicente V
Title Platelet receptors and signaling in the dynamics of thrombus formation.
Journal Reference Authors Banno A, Ginsberg MH
Title Integrin activation.
Journal Reference Authors Angiolillo DJ, Ferreiro JL
Title Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions.
Journal Reference Authors Joo SJ
Title Mechanisms of Platelet Activation and Integrin alphaIIbeta3.
Journal Reference Authors Harper MT, Poole AW
Title Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.
Journal Reference Authors Fitch-Tewfik JL, Flaumenhaft R
Title Platelet granule exocytosis: a comparison with chromaffin cells.
Journal Reference Authors Boylan B, Gao C, Rathore V, Gill JC, Newman DK, Newman PJ
Title Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets.
Journal Related ko00590 Arachidonic acid metabolism
ko04610 Complement and coagulation cascades
LinkDB All DBs
