Entry Name JAK-STAT signaling pathway
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K05436 thymic stromal lymphopoietin
K05068 interleukin 2 receptor alpha
K05069 interleukin 2 receptor beta
K05070 interleukin 2 receptor gamma
K05074 interleukin 15 receptor alpha
K05075 interleukin 21 receptor
K05078 thymic stromal-derived lymphopoietin receptor
K05427 granulocyte-macrophage colony-stimulating factor
K04737 interleukin 3 receptor alpha
K05067 interleukin 5 receptor alpha
K05066 granulocyte-macrophage colony-stimulating factor receptor alpha
K04738 cytokine receptor common subunit beta
K22629 interleukin 27 subunit alpha
K05419 leukemia inhibitory factor
K05420 ciliary neurotrophic factor
K05421 cardiotrophin-like cytokine factor 1
K05060 interleukin 6 signal transducer
K05056 interleukin 11 receptor alpha
K05076 interleukin 13 receptor alpha-1
K05077 interleukin 13 receptor alpha-2
K19598 interleukin 27 receptor alpha
K22630 interleukin 31 receptor subunit alpha
K05058 leukemia inhibitory factor receptor
K05059 ciliary neurotrophic factor receptor
K05134 interleukin 10 receptor alpha
K05135 interleukin 10 receptor beta
K05136 interleukin 20 receptor alpha
K05137 interleukin 20 receptor beta
K05138 interleukin 22 receptor alpha 1
K05139 interleukin 22 receptor alpha 2
K05426 interleukin 23 subunit alpha
K05063 interleukin 12 receptor beta-1
K05064 interleukin 12 receptor beta-2
K05065 interleukin 23 receptor
K05423 granulocyte colony-stimulating factor
K05079 erythropoietin receptor
K05080 growth hormone receptor
K05082 thrombopoietin receptor
K05061 granulocyte colony-stimulating factor receptor
K19599 cytokine receptor domeless
K05140 interferon lambda receptor 1
K05132 interferon gamma receptor 1
K05133 interferon gamma receptor 2
K04357 epidermal growth factor
K04359 platelet-derived growth factor subunit A
K17386 platelet-derived growth factor subunit B
K11220 signal transducer and activator of transcription 1
K11221 signal transducer and activator of transcription 2
K04692 signal transducer and activator of transcription 3
K11222 signal transducer and activator of transcription 4
K11223 signal transducer and activator of transcription 5A
K11224 signal transducer and activator of transcription 5B
K11225 signal transducer and activator of transcription 6
K04693 interferon regulatory factor 9
K04701 cytokine inducible SH2-containing protein
K04694 suppressor of cytokine signaling 1
K04695 suppressor of cytokine signaling 2
K04696 suppressor of cytokine signaling 3
K04697 suppressor of cytokine signaling 4
K04698 suppressor of cytokine signaling 5
K04699 suppressor of cytokine signaling 6/7
K02161 apoptosis regulator Bcl-2
K02539 myeloid leukemia cell differntiation protein MCL-1
K04570 Bcl-2-like 1 (apoptosis regulator Bcl-X)
K04702 proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1 ]
K04377 Myc proto-oncogene protein
K04503 G1/S-specific cyclin-D1
K10151 G1/S-specific cyclin-D2
K10152 G1/S-specific cyclin-D3
K06625 cyclin-dependent kinase inhibitor 1A
K05640 glial fibrillary acidic protein
K04705 signal transducing adaptor molecule
K04706 E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]
K16063 E3 SUMO-protein ligase PIAS2 [EC:2.3.2.-]
K16064 E3 SUMO-protein ligase PIAS3 [EC:2.3.2.-]
K14365 four and a half LIM domains protein 1
K07293 tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48 ]
K04364 growth factor receptor-bound protein 2
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related ko04060 Cytokine-cytokine receptor interaction
ko04120 Ubiquitin mediated proteolysis
LinkDB All DBs 
