KEGG   PATHWAY: ko05012
Entry
ko05012                     Pathway                                
Name
Parkinson disease
Description
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ko05012  Parkinson disease
ko05012

Disease
H00057  Parkinson disease
Orthology
K04266  adenosine receptor A2a
K04633  guanine nucleotide-binding protein G(olf) subunit alpha
K04632  guanine nucleotide-binding protein G(s) subunit alpha
K04145  dopamine receptor D2
K04630  guanine nucleotide-binding protein G(i) subunit alpha
K08045  adenylate cyclase 5 [EC:4.6.1.1]
K04345  protein kinase A [EC:2.7.11.11]
K04144  dopamine receptor D1
K03178  ubiquitin-activating enzyme E1 [EC:6.2.1.45]
K10698  ubiquitin-activating enzyme E1-like [EC:6.2.1.45]
K02927  ubiquitin-large subunit ribosomal protein L40e
K02977  ubiquitin-small subunit ribosomal protein S27Ae
K04551  ubiquitin B
K08770  ubiquitin C
K04552  ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]
K04553  ubiquitin/ISG15-conjugating enzyme E2 L6 [EC:2.3.2.23]
K04554  ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
K10578  ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]
K04555  ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
K10575  ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
K04556  parkin [EC:2.3.2.31]
K04528  alpha-synuclein
K04243  prosaposin receptor
K04557  septin 5
K04558  synphilin-1
K02730  20S proteasome subunit alpha 1 [EC:3.4.25.1]
K02726  20S proteasome subunit alpha 2 [EC:3.4.25.1]
K02728  20S proteasome subunit alpha 3 [EC:3.4.25.1]
K02731  20S proteasome subunit alpha 4 [EC:3.4.25.1]
K02729  20S proteasome subunit alpha 5 [EC:3.4.25.1]
K02725  20S proteasome subunit alpha 6 [EC:3.4.25.1]
K02727  20S proteasome subunit alpha 7 [EC:3.4.25.1]
K02738  20S proteasome subunit beta 1 [EC:3.4.25.1]
K02739  20S proteasome subunit beta 2 [EC:3.4.25.1]
K02735  20S proteasome subunit beta 3 [EC:3.4.25.1]
K02734  20S proteasome subunit beta 4 [EC:3.4.25.1]
K02737  20S proteasome subunit beta 5 [EC:3.4.25.1]
K02732  20S proteasome subunit beta 6 [EC:3.4.25.1]
K02736  20S proteasome subunit beta 7 [EC:3.4.25.1]
K03061  26S proteasome regulatory subunit T1
K03062  26S proteasome regulatory subunit T2
K03063  26S proteasome regulatory subunit T3
K03064  26S proteasome regulatory subunit T4
K03065  26S proteasome regulatory subunit T5
K03066  26S proteasome regulatory subunit T6
K03028  26S proteasome regulatory subunit N1
K03032  26S proteasome regulatory subunit N2
K03033  26S proteasome regulatory subunit N3
K06693  26S proteasome regulatory subunit N4
K03035  26S proteasome regulatory subunit N5
K03036  26S proteasome regulatory subunit N6
K03037  26S proteasome regulatory subunit N7
K03038  26S proteasome regulatory subunit N8
K03039  26S proteasome regulatory subunit N9
K03029  26S proteasome regulatory subunit N10
K03030  26S proteasome regulatory subunit N11
K03031  26S proteasome regulatory subunit N12
K06691  26S proteasome regulatory subunit N13
K10881  26 proteasome complex subunit DSS1
K05611  ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12]
K02183  calmodulin
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04380  microtubule-associated protein tau
K04963  ryanodine receptor 3
K04958  inositol 1,4,5-triphosphate receptor type 1
K04959  inositol 1,4,5-triphosphate receptor type 2
K04960  inositol 1,4,5-triphosphate receptor type 3
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K09490  endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
K09054  cyclic AMP-dependent transcription factor ATF-6 alpha
K04452  DNA damage-inducible transcript 3
K08852  serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K09027  X box-binding protein 1
K08860  eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K03237  translation initiation factor 2 subunit 1
K04374  cyclic AMP-dependent transcription factor ATF-4
K00501  tyrosine 3-monooxygenase [EC:1.14.16.2]
K00274  monoamine oxidase [EC:1.4.3.4]
K05036  solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
K08155  MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
K21398  natural resistance-associated macrophage protein 2
K14709  solute carrier family 39 (zinc transporter), member 1/2/3
K14710  solute carrier family 39 (zinc transporter), member 4
K14711  solute carrier family 39 (zinc transporter), member 5
K14712  solute carrier family 39 (zinc transporter), member 6
K14713  solute carrier family 39 (zinc transporter), member 7
K14714  solute carrier family 39 (zinc transporter), member 8
K14715  solute carrier family 39 (zinc transporter), member 9
K14716  solute carrier family 39 (zinc transporter), member 10
K14717  solute carrier family 39 (zinc transporter), member 11
K14718  solute carrier family 39 (zinc transporter), member 12
K14719  solute carrier family 39 (zinc transporter), member 13
K14720  solute carrier family 39 (zinc transporter), member 14
K03878  NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
K03879  NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]
K03880  NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]
K03881  NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]
K03882  NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]
K03883  NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]
K03884  NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]
K03942  NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2]
K03943  NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2]
K03944  NADH dehydrogenase (ubiquinone) flavoprotein 3
K03945  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
K03946  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
K03947  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
K03948  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03949  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
K03950  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
K03951  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
K03952  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
K03953  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
K03954  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
K03955  NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein
K03956  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
K11352  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
K11353  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
K03957  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
K03958  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
K03959  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
K03960  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
K03961  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
K03962  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
K03963  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
K03964  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
K03965  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
K03966  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
K11351  NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
K03934  NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2]
K03935  NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2]
K03936  NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2]
K03937  NADH dehydrogenase (ubiquinone) Fe-S protein 4
K03938  NADH dehydrogenase (ubiquinone) Fe-S protein 5
K03939  NADH dehydrogenase (ubiquinone) Fe-S protein 6
K03940  NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2]
K03941  NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2]
K03967  NADH dehydrogenase (ubiquinone) 1 subunit C1
K03968  NADH dehydrogenase (ubiquinone) 1 subunit C2
K00234  succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235  succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00236  succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237  succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00411  ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K00412  ubiquinol-cytochrome c reductase cytochrome b subunit
K00413  ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00414  ubiquinol-cytochrome c reductase core subunit 1
K00415  ubiquinol-cytochrome c reductase core subunit 2
K00416  ubiquinol-cytochrome c reductase subunit 6
K00417  ubiquinol-cytochrome c reductase subunit 7
K00418  ubiquinol-cytochrome c reductase subunit 8
K00419  ubiquinol-cytochrome c reductase subunit 9
K00420  ubiquinol-cytochrome c reductase subunit 10
K02262  cytochrome c oxidase subunit 3
K02256  cytochrome c oxidase subunit 1 [EC:7.1.1.9]
K02261  cytochrome c oxidase subunit 2
K02263  cytochrome c oxidase subunit 4
K02264  cytochrome c oxidase subunit 5a
K02265  cytochrome c oxidase subunit 5b
K02266  cytochrome c oxidase subunit 6a
K02267  cytochrome c oxidase subunit 6b
K02268  cytochrome c oxidase subunit 6c
K02270  cytochrome c oxidase subunit 7a
K02271  cytochrome c oxidase subunit 7b
K02272  cytochrome c oxidase subunit 7c
K02273  cytochrome c oxidase subunit 8
K02132  F-type H+-transporting ATPase subunit alpha
K02133  F-type H+-transporting ATPase subunit beta [EC:7.1.2.2]
K02136  F-type H+-transporting ATPase subunit gamma
K02134  F-type H+-transporting ATPase subunit delta
K02135  F-type H+-transporting ATPase subunit epsilon
K02126  F-type H+-transporting ATPase subunit a
K02127  F-type H+-transporting ATPase subunit b
K02128  F-type H+-transporting ATPase subunit c
K02138  F-type H+-transporting ATPase subunit d
K02137  F-type H+-transporting ATPase subunit O
K02131  F-type H+-transporting ATPase subunit 6
K02125  F-type H+-transporting ATPase subunit 8
K05688  PTEN induced putative kinase 1 [EC:2.7.11.1]
K20858  calcium uniporter protein, mitochondrial
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
K08669  HtrA serine peptidase 2 [EC:3.4.21.108]
K09488  TNF receptor-associated protein 1
K05862  voltage-dependent anion channel protein 1
K15040  voltage-dependent anion channel protein 2
K15041  voltage-dependent anion channel protein 3
K05863  solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K09565  peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
K08738  cytochrome c
K02084  apoptotic protease-activating factor
K04399  caspase 9 [EC:3.4.22.62]
K02187  caspase 3 [EC:3.4.22.56]
K05687  protein DJ-1 [EC:3.5.1.124]
K04570  Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02159  apoptosis regulator BAX
K21356  mitofusin 1 [EC:3.6.5.-]
K06030  mitofusin 2 [EC:3.6.5.-]
K10396  kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]
K10407  kinesin light chain
K07374  tubulin alpha
K07375  tubulin beta
K04451  tumor protein p53
K21278  dual specificity protein phosphatase 1 [EC:3.1.3.16 3.1.3.48]
K05638  nuclear factor erythroid 2-related factor 2
K03671  thioredoxin
K02308  death-associated protein 6
K04426  mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04565  superoxide dismutase, Cu-Zn family [EC:1.15.1.1]
K10456  kelch-like protein 19
Compound
C00002  ATP
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00020  AMP
C00027  Hydrogen peroxide
C00034  Manganese
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00212  Adenosine
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
C04043  3,4-Dihydroxyphenylacetaldehyde
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C14701  Paraquat
C15231  Maneb
C16844  Hydroxyl radical
C17755  Dopamine quinone
C22381  Reactive oxygen species
Reference
PMID:16495942
  Authors
Abou-Sleiman PM, Muqit MM, Wood NW
  Title
Expanding insights of mitochondrial dysfunction in Parkinson's disease.
  Journal
Nat Rev Neurosci 7:207-19 (2006)
DOI:10.1038/nrn1868
Reference
PMID:12938733
  Authors
Lim KL, Lim TM
  Title
Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes.
  Journal
IUBMB Life 55:315-22 (2003)
DOI:10.1080/1521654031000153030
Reference
PMID:26501339
  Authors
Bobela W, Aebischer P, Schneider BL
  Title
Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.
  Journal
Biomolecules 5:2675-700 (2015)
DOI:10.3390/biom5042675
Reference
PMID:15767499
  Authors
Eriksen JL, Wszolek Z, Petrucelli L
  Title
Molecular pathogenesis of Parkinson disease.
  Journal
Arch Neurol 62:353-7 (2005)
DOI:10.1001/archneur.62.3.353
Reference
PMID:16972273
  Authors
Olanow CW, McNaught KS
  Title
Ubiquitin-proteasome system and Parkinson's disease.
  Journal
Mov Disord 21:1806-23 (2006)
DOI:10.1002/mds.21013
Reference
PMID:18047737
  Authors
Lim KL, Tan JM
  Title
Role of the ubiquitin proteasome system in Parkinson's disease.
  Journal
BMC Biochem 8 Suppl 1:S13 (2007)
DOI:10.1186/1471-2091-8-S1-S13
Reference
PMID:29090092
  Authors
Maiti P, Manna J, Dunbar GL
  Title
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments.
  Journal
Transl Neurodegener 6:28 (2017)
DOI:10.1186/s40035-017-0099-z
Reference
PMID:12814656
  Authors
Dev KK, van der Putten H, Sommer B, Rovelli G
  Title
Part I: parkin-associated proteins and Parkinson's disease.
  Journal
Neuropharmacology 45:1-13 (2003)
DOI:10.1016/s0028-3908(02)00337-4
Reference
PMID:20495568
  Authors
Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G
  Title
Missing pieces in the Parkinson's disease puzzle.
  Journal
Nat Med 16:653-61 (2010)
DOI:10.1038/nm.2165
Reference
PMID:24781149
  Authors
Cali T, Ottolini D, Brini M
  Title
Calcium signaling in Parkinson's disease.
  Journal
Cell Tissue Res 357:439-54 (2014)
DOI:10.1007/s00441-014-1866-0
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:28468938
  Authors
Zaichick SV, McGrath KM, Caraveo G
  Title
The role of Ca(2+) signaling in Parkinson's disease.
  Journal
Dis Model Mech 10:519-535 (2017)
DOI:10.1242/dmm.028738
Reference
PMID:28838811
  Authors
Ludtmann MHR, Abramov AY
  Title
Mitochondrial calcium imbalance in Parkinson's disease.
  Journal
Neurosci Lett 663:86-90 (2018)
DOI:10.1016/j.neulet.2017.08.044
Reference
PMID:19663908
  Authors
Sandebring A, Dehvari N, Perez-Manso M, Thomas KJ, Karpilovski E, Cookson MR, Cowburn RF, Cedazo-Minguez A
  Title
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
  Journal
FEBS J 276:5041-52 (2009)
DOI:10.1111/j.1742-4658.2009.07201.x
Reference
PMID:23352769
  Authors
Mercado G, Valdes P, Hetz C
  Title
An ERcentric view of Parkinson's disease.
  Journal
Trends Mol Med 19:165-75 (2013)
DOI:10.1016/j.molmed.2012.12.005
Reference
PMID:27103567
  Authors
Mercado G, Castillo V, Soto P, Sidhu A
  Title
ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway.
  Journal
Brain Res 1648:626-632 (2016)
DOI:10.1016/j.brainres.2016.04.042
Reference
PMID:26297973
  Authors
Tsujii S, Ishisaka M, Hara H
  Title
Modulation of endoplasmic reticulum stress in Parkinson's disease.
  Journal
Eur J Pharmacol 765:154-6 (2015)
DOI:10.1016/j.ejphar.2015.08.033
Reference
PMID:31100053
  Authors
Shah A, Chao J, Legido-Quigley C, Chang RC
  Title
Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.
  Journal
Nutr Neurosci 1-16 (2019)
DOI:10.1080/1028415X.2019.1613764
Reference
PMID:24548101
  Authors
Segura-Aguilar J, Paris I, Munoz P, Ferrari E, Zecca L, Zucca FA
  Title
Protective and toxic roles of dopamine in Parkinson's disease.
  Journal
J Neurochem 129:898-915 (2014)
DOI:10.1111/jnc.12686
Reference
PMID:31587020
  Authors
Jesko H, Lenkiewicz AM, Wilkaniec A, Adamczyk A
  Title
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
  Journal
Acta Neurobiol Exp (Wars) 79:276-289 (2019)
Reference
PMID:15189334
  Authors
Perez RG, Hastings TG
  Title
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
  Journal
J Neurochem 89:1318-24 (2004)
DOI:10.1111/j.1471-4159.2004.02423.x
Reference
PMID:26487845
  Authors
Segura-Aguilar J
  Title
A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
  Journal
Neural Regen Res 10:1225-7 (2015)
DOI:10.4103/1673-5374.162750
Reference
PMID:27546335
  Authors
Bose A, Beal MF
  Title
Mitochondrial dysfunction in Parkinson's disease.
  Journal
J Neurochem 139 Suppl 1:216-231 (2016)
DOI:10.1111/jnc.13731
Reference
PMID:27581196
  Authors
Cieri D, Brini M, Cali T
  Title
Emerging (and converging) pathways in Parkinson's disease: keeping mitochondrial wellness.
  Journal
Biochem Biophys Res Commun 483:1020-1030 (2017)
DOI:10.1016/j.bbrc.2016.08.153
Reference
PMID:27829983
  Authors
Mack JM, Schamne MG, Sampaio TB, Pertile RA, Fernandes PA, Markus RP, Prediger RD
  Title
Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.
  Journal
Oxid Med Cell Longev 2016:3472032 (2016)
DOI:10.1155/2016/3472032
Reference
PMID:21674642
  Authors
Cali T, Ottolini D, Brini M
  Title
Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease.
  Journal
Biofactors 37:228-40 (2011)
DOI:10.1002/biof.159
Reference
PMID:24522549
  Authors
Gaki GS, Papavassiliou AG
  Title
Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease.
  Journal
Neuromolecular Med 16:217-30 (2014)
DOI:10.1007/s12017-014-8294-x
Reference
PMID:25761946
  Authors
Franco-Iborra S, Vila M, Perier C
  Title
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
  Journal
Neuroscientist 22:266-77 (2016)
DOI:10.1177/1073858415574600
Reference
PMID:22926193
  Authors
de Vries RL, Przedborski S
  Title
Mitophagy and Parkinson's disease: be eaten to stay healthy.
  Journal
Mol Cell Neurosci 55:37-43 (2013)
DOI:10.1016/j.mcn.2012.07.008
Reference
PMID:20736035
  Authors
Deas E, Wood NW, Plun-Favreau H
  Title
Mitophagy and Parkinson's disease: the PINK1-parkin link.
  Journal
Biochim Biophys Acta 1813:623-33 (2011)
DOI:10.1016/j.bbamcr.2010.08.007
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:27911343
  Authors
Truban D, Hou X, Caulfield TR, Fiesel FC, Springer W
  Title
PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
  Journal
J Parkinsons Dis 7:13-29 (2017)
DOI:10.3233/JPD-160989
Reference
PMID:28823929
  Authors
Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M
  Title
Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
  Journal
Neurobiol Dis 108:65-72 (2017)
DOI:10.1016/j.nbd.2017.08.005
Reference
PMID:29147906
  Authors
Oh SE, Mouradian MM
  Title
Regulation of Signal Transduction by DJ-1.
  Journal
Adv Exp Med Biol 1037:97-131 (2017)
DOI:10.1007/978-981-10-6583-5_8
Reference
PMID:31054074
  Authors
Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY
  Title
Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
  Journal
J Bioenerg Biomembr 51:175-188 (2019)
DOI:10.1007/s10863-019-09798-4
Reference
PMID:30370500
  Authors
Melo TQ, Copray SJCVM, Ferrari MFR
  Title
Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.
  Journal
Neurochem Res 43:2212-2223 (2018)
DOI:10.1007/s11064-018-2673-x
Reference
PMID:30937538
  Authors
Zhai S, Shen W, Graves SM, Surmeier DJ
  Title
Dopaminergic modulation of striatal function and Parkinson's disease.
  Journal
J Neural Transm (Vienna) 126:411-422 (2019)
DOI:10.1007/s00702-019-01997-y
Reference
PMID:29720658
  Authors
Parker JG, Marshall JD, Ahanonu B, Wu YW, Kim TH, Grewe BF, Zhang Y, Li JZ, Ding JB, Ehlers MD, Schnitzer MJ
  Title
Diametric neural ensemble dynamics in parkinsonian and dyskinetic states.
  Journal
Nature 557:177-182 (2018)
DOI:10.1038/s41586-018-0090-6
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