Entry Name Gastric cancer
Description Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological classification gastric cancer is divided into two distinct histological groups - the intestinal and diffuse types. Several genetic changes have been identified in intestinal-type GC. The intestinal metaplasia is characterized by mutations in p53 gene, reduced expression of retinoic acid receptor beta (RAR-beta) and hTERT expression. Gastric adenomas furthermore display mutations in the APC gene, reduced p27 expression and cyclin E amplification. In addition, amplification and overexpression of c-ErbB2, reduced TGF-beta receptor type I (TGFBRI) expression and complete loss of p27 expression are commonly observed in more advanced GC. The main molecular changes observed in diffuse-type GCs include loss of E-cadherin function by mutations in CDH1 and amplification of MET and FGFR2F.
Class Human Diseases; Cancer: specific typesBRITE hierarchy
Pathway map Ortholog table Disease Orthology K06811 cadherin 17, LI cadherin
K22244 regenerating islet-derived protein 4
K05658 ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2 ]
K06625 cyclin-dependent kinase inhibitor 1A
K04402 growth arrest and DNA-damage-inducible protein
K02159 apoptosis regulator BAX
K14021 Bcl-2 homologous antagonist/killer
K10140 DNA damage-binding protein 2
K08528 retinoic acid receptor beta
K08524 retinoid X receptor alpha
K08525 retinoid X receptor beta
K08526 retinoid X receptor gamma
K03209 wingless-type MMTV integration site family, member 1
K00182 wingless-type MMTV integration site family, member 2
K00312 wingless-type MMTV integration site family, member 3
K00408 wingless-type MMTV integration site family, member 4
K00444 wingless-type MMTV integration site family, member 5
K00445 wingless-type MMTV integration site family, member 6
K00572 wingless-type MMTV integration site family, member 7
K00714 wingless-type MMTV integration site family, member 8
K01064 wingless-type MMTV integration site family, member 9
K01357 wingless-type MMTV integration site family, member 10
K01384 wingless-type MMTV integration site family, member 11
K01558 wingless-type MMTV integration site family, member 16
K03068 low density lipoprotein receptor-related protein 5/6
K02353 segment polarity protein dishevelled
K03069 frequently rearranged in advanced T-cell lymphomas 1
K03096 frequently rearranged in advanced T-cell lymphomas 2
K02085 adenomatosis polyposis coli protein
K04490 transcription factor 7-like 1
K04491 transcription factor 7-like 2
K04492 lymphoid enhancer-binding factor 1
K04377 Myc proto-oncogene protein
K04503 G1/S-specific cyclin-D1
K22183 telomerase RNA component
K04357 epidermal growth factor
K06279 SHC-transforming protein 1
K17447 SHC-transforming protein 2
K17448 SHC-transforming protein 3
K17449 SHC-transforming protein 4
K04364 growth factor receptor-bound protein 2
K08845 A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04365 B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02161 apoptosis regulator Bcl-2
K08734 DNA mismatch repair protein MLH1
K06624 cyclin-dependent kinase inhibitor 1B
K06626 G1/S-specific cyclin-E1
K06618 retinoblastoma-associated protein
K17454 transcription factor E2F1
K09389 transcription factor E2F2
K06620 transcription factor E2F3
K13375 transforming growth factor beta-1
K13376 transforming growth factor beta-2
K13377 transforming growth factor beta-3
K04500 mothers against decapentaplegic homolog 2
K23605 mothers against decapentaplegic homolog 3
K04501 mothers against decapentaplegic homolog 4
K04685 cyclin-dependent kinase inhibitor 2B
K05689 cadherin 1, type 1, E-cadherin
K05460 hepatocyte growth factor
K18496 fibroblast growth factor 1
K18497 fibroblast growth factor 2
K04358 fibroblast growth factor
K22603 fibroblast growth factor 19
K22429 fibroblast growth factor 21
K22428 fibroblast growth factor 23
K09593 GRB2-associated-binding protein 1
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Tan P, Yeoh KG
Title Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma.
Journal Reference Authors Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C
Title Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.
Journal Reference Authors Stock M, Otto F
Title Gene deregulation in gastric cancer.
Journal Reference Authors Panani AD
Title Cytogenetic and molecular aspects of gastric cancer: clinical implications.
Journal Reference Authors Vauhkonen M, Vauhkonen H, Sipponen P
Title Pathology and molecular biology of gastric cancer.
Journal Reference Authors Smith MG, Hold GL, Tahara E, El-Omar EM.
Title Cellular and molecular aspects of gastric cancer.
Journal Reference Authors Zheng L, Wang L, Ajani J, Xie K.
Title Molecular basis of gastric cancer development and progression.
Journal Reference Authors Yuasa Y
Title Control of gut differentiation and intestinal-type gastric carcinogenesis.
Journal Reference Authors Wessler S, Krisch LM, Elmer DP, Aberger F
Title From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases.
Journal Reference Authors Yan LH, Wei WY, Xie YB, Xiao Q
Title New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer.
Journal Reference Authors Hayashi K, Yokozaki H, Goodison S, Oue N, Suzuki T, Lotan R, Yasui W, Tahara E
Title Inactivation of retinoic acid receptor beta by promoter CpG hypermethylation in gastric cancer.
Journal Reference Authors Li X, Wu WK, Xing R, Wong SH, Liu Y, Fang X, Zhang Y, Wang M, Wang J, Li L, Zhou Y, Tang S, Peng S, Qiu K, Chen L, Chen K, Yang H, Zhang W, Chan MT, Lu Y, Sung JJ, Yu J
Title Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability.
Journal Reference Authors Wadhwa R, Song S, Lee JS, Yao Y, Wei Q, Ajani JA
Title Gastric cancer-molecular and clinical dimensions.
Journal Reference Authors Bertotti A, Sassi F
Title Molecular Pathways: Sensitivity and Resistance to Anti-EGFR Antibodies.
Journal Reference Authors Appleman LJ
Title MET signaling pathway: a rational target for cancer therapy.
Journal Reference Authors Eder JP, Vande Woude GF, Boerner SA, LoRusso PM
Title Novel therapeutic inhibitors of the c-Met signaling pathway in cancer.
Journal Reference Authors Feng Y, Ma PC
Title Anti-MET targeted therapy has come of age: the first durable complete response with MetMAb in metastatic gastric cancer.
Journal Reference Authors Katoh M, Nakagama H
Title FGF receptors: cancer biology and therapeutics.
Journal Reference Authors Katoh M
Title FGFR2 abnormalities underlie a spectrum of bone, skin, and cancer pathologies.
Journal Reference Authors Katoh M
Title Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics.
Journal Related ko05120 Epithelial cell signaling in Helicobacter pylori infection
LinkDB All DBs
