KEGG   PATHWAY: rn00061
Entry
rn00061                     Pathway                                
Name
Fatty acid biosynthesis
Class
Metabolism; Lipid metabolism
Pathway map
rn00061  Fatty acid biosynthesis
rn00061

Module
M00082  Fatty acid biosynthesis, initiation [PATH:rn00061]
M00083  Fatty acid biosynthesis, elongation [PATH:rn00061]
M00086  beta-Oxidation, acyl-CoA synthesis [PATH:rn00061]
M00873  Fatty acid biosynthesis in mitochondria, animals [PATH:rn00061]
M00874  Fatty acid biosynthesis in mitochondria, fungi [PATH:rn00061]
Other DBs
GO: 0006633
Reaction
R00390  long-chain-fatty-acid:CoA ligase (AMP-forming)
R00742  acetyl-CoA:carbon-dioxide ligase (ADP-forming)
R01280  palmitate:CoA ligase (AMP-forming)
R01403  acyl-[acyl-carrier-protein]:NAD+ oxidoreductase
R01404  acyl-[acyl-carrier protein]:NADP+ oxidoreductase
R01624  acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase
R01626  malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase
R01706  hexadecanoyl-[acyl-carrier protein] hydrolase
R02767  (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP+ oxidoreductase
R02768  acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
R02814  oleoyl-[acyl-carrier-protein] hydrolase
R03370  stearoyl-[acyl-carrier protein],reduced-ferredoxin:oxygen oxidoreductase (9,10 cis-dehydrogenating)
R04014  dodecanoyl-[acyl-carrier-protein] hydrolase
R04355  acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
R04428  (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase
R04429  butyryl-[acp]:NAD+ trans-2-oxidoreductase
R04430  butyryl-[acp]:NADP+ trans-2-oxidoreductase
R04533  (3R)-3-hydroxybutanoyl-[acyl-carrier protein]:NADP+ oxidoreductase
R04534  (3R)-3-hydroxydecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase
R04535  (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase
R04536  (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase
R04537  (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase
R04543  (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein]:NADP+ oxidoreductase
R04544  (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase
R04566  (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase
R04568  (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] hydro-lyase
R04724  dodecanoyl-[acp]:NAD+ trans-2-oxidoreductase
R04725  dodecanoyl-[acp]:NADP+ trans-2-oxidoreductase
R04726  dodecanoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
R04952  butyryl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
R04953  (3R)-3-hydroxyhexanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase
R04954  (3R)-3-hydroxyhexanoyl-[acyl-carrier-protein] hydro-lyase
R04955  hexanoyl-[acp]:NAD+ trans-2-oxidoreductase
R04956  hexanoyl-[acp]:NADP+ trans-2-oxidoreductase
R04957  hexanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
R04958  octanoyl-[acp]:NAD+ trans-2-oxidoreductase
R04959  octanoyl-[acp]:NADP+ trans-2-oxidoreductase
R04960  octanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
R04961  decanoyl-[acp]:NAD+ trans-2-oxidoreductase
R04962  decanoyl-[acp]:NADP+ trans-2-oxidoreductase
R04963  decanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
R04964  (3R)-3-hydroxydodecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase
R04965  (3R)-3-hydroxydodecanoyl-[acyl-carrier-protein] hydro-lyase
R04966  tetradecanoyl-[acp]:NAD+ trans-2-oxidoreductase
R04967  tetradecanoyl-[acp]:NADP+ trans-2-oxidoreductase
R04968  tetradecanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
R04969  hexadecanoyl-[acp]:NAD+ trans-2-oxidoreductase
R04970  hexadecanoyl-[acp]:NADP+ trans-2-oxidoreductase
R05188  acyl-CoA:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
R05190  acyl-CoA:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing)
R07639  decenoyl-[acyl-carrier-protein] Delta2-trans-Delta3-cis-isomerase
R07762   
R07763   
R07764   
R07765  octadecanoyl-[acp]:NAD+ trans-2-oxidoreductase
R08157  octanoyl-[acyl-carrier protein] hydrolase
R08158  decanoyl-[acyl-carrier protein] hydrolase
R08159  tetradecanoyl-[acyl-carrier protein] hydrolase
R08161  hexadecanoyl-[acyl-carrier protein],reduced-ferredoxin:oxygen oxidoreductase (9,10 cis-dehydrogenating)
R08162  hexadecenoyl-[acyl-carrier protein] hydrolase
R08163  octadecanoyl-[acyl-carrier protein] hydrolase
R10208  (3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming)
R10700  palmitoyl-[acp]:CoA S-palmitoyltransferase
R10707  acetyl-CoA:malonyl-[acyl-carrier protein] C-acetyltransferase (decarboxylating)
R10714   
R12300  malonate:CoA ligase (AMP-forming)
R12328  acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, NADH)
R12329  long-chain acyl-[acyl-carrier protein] hydrolase
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
rn00020  Citrate cycle (TCA cycle)
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn00410  beta-Alanine metabolism
rn00561  Glycerolipid metabolism
rn00564  Glycerophospholipid metabolism
rn00620  Pyruvate metabolism
rn00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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