KEGG   REACTION: R00014
Entry
R00014                      Reaction                               
Name
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Definition
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
Equation
Comment
2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699), subsequently R03270
TPP-dependent enzymatic reaction (see R00006), subsequently R03050
TPP-dependent enzymatic reaction (see R00226), subsequently R04672
TPP-dependent enzymatic reaction (see R00224), subsequently R00755
TPP-dependent enzymatic reaction (see R08648), subsequently R04673
Reaction class
RC00027  C00068_C05125
RC02744  C00022_C05125
Enzyme
1.2.4.1         2.2.1.6         4.1.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
rn00785  Lipoic acid metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1
     R00014  Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
 2. Transferase reactions
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.6
     R00014  Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.1
     R00014  Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K01568  pyruvate decarboxylase [EC:4.1.1.1]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
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