KEGG   REACTION: R00084
Entry
R00084                      Reaction                               
Name
porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing);
porphobilinogen ammonia-lyase (polymerizing)
Definition
4 Porphobilinogen + H2O <=> Hydroxymethylbilane + 4 Ammonia
Equation
4 C00931 + C00001 <=> C01024 + 4 C00014
Comment
multi-step reaction
Reaction class
RC02317  C00931_C01024
Enzyme
2.5.1.61
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00121  Heme biosynthesis, plants and bacteria, glutamate => heme
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
M00868  Heme biosynthesis, animals and fungi, glycine => heme
M00926  Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.61
     R00084  4 Porphobilinogen + H2O <=> Hydroxymethylbilane + 4 Ammonia
Orthology
K01749  hydroxymethylbilane synthase [EC:2.5.1.61]
Other DBs
RHEA: 13188
LinkDB

DBGET integrated database retrieval system