REACTION: R00102
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Entry
R00102 Reaction
Name
NAD+ glycohydrolase
Definition
NAD+ + H2O <=> Nicotinamide + ADP-ribose
Equation
C00003
+
C00001
<=>
C00153
+
C00301
Reaction class
RC00033
C00003_C00153
RC00485
C00003_C00301
Enzyme
3.2.2.5
3.2.2.6
3.5.1.-
Pathway
rn00760
Nicotinate and nicotinamide metabolism
rn01100
Metabolic pathways
Brite
Enzymatic reactions [BR:
br08201
]
3. Hydrolase reactions
3.2 Glycosylases
3.2.2 Hydrolysing N-glycosyl compounds
3.2.2.5
R00102 NAD+ + H2O <=> Nicotinamide + ADP-ribose
3.2.2.6
R00102 NAD+ + H2O <=> Nicotinamide + ADP-ribose
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.-
R00102 NAD+ + H2O <=> Nicotinamide + ADP-ribose
BRITE hierarchy
Orthology
K01242
ADP-ribosyl cyclase 1 [EC:
3.2.2.6
2.4.99.20
]
K18152
ADP-ribosyl cyclase 2 [EC:
3.2.2.6
2.4.99.20
]
K18153
NAD+ glycohydrolase [EC:
3.2.2.5
]
K19980
ADP-ribosyltransferase 2 / NAD+ glycohydrolase [EC:
2.4.2.31
3.2.2.5
]
Reference
1 [PMID:
19001417
]
Authors
Belenky P, Christensen KC, Gazzaniga F, Pletnev AA, Brenner C.
Title
Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.
Journal
J Biol Chem 284:158-64 (2009)
DOI:
10.1074/jbc.M807976200
Other DBs
RHEA:
16304
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