KEGG   REACTION: R00705
Entry
R00705                      Reaction                               
Name
3-oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating)
Definition
3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Equation
C00222 + C00010 + C00003 <=> C00024 + C00011 + C00004 + C00080
Comment
NADP+ (ec 1.2.1.18, see R00706)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00024
RC02723  C00024_C00222
Enzyme
1.2.1.18        1.2.1.27
Pathway
rn00410  beta-Alanine metabolism
rn00562  Inositol phosphate metabolism
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
rn01200  Carbon metabolism
Module
M00013  Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.18
     R00705  3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
    1.2.1.27
     R00705  3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Orthology
K00140  malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]
Other DBs
RHEA: 22995
LinkDB

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