KEGG   REACTION: R00707
Entry
R00707                      Reaction                               
Name
(S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase
Definition
(S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+
Equation
C03912 + C00003 + 2 C00001 <=> C00025 + C00004 + C00080
Comment
two-step reaction (see R03314+R00245)
NADPH (see R00708)
Reaction class
RC00001  C00003_C00004
RC00216  C00025_C03912
Enzyme
1.2.1.88
Pathway
rn00250  Alanine, aspartate and glutamate metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.88
     R00707  (S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+
Orthology
K00294  1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]
K13821  RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
Other DBs
RHEA: 16420
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