KEGG   REACTION: R00940
Entry
R00940                      Reaction                               
Name
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Definition
Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
Equation
C00101 + 2 C00006 <=> C00504 + 2 C00005 + 2 C00080
Comment
two-step reaction (see R00939+R02236)
NAD+ (see R00937)
Reaction class
RC00001  C00005_C00006
RC00110  C00101_C00504
Enzyme
1.5.1.3
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3
     R00940  Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
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