KEGG   REACTION: R01221
Entry
R01221                      Reaction                               
Name
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding);
glycine cleavage system
Definition
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
Equation
C00037 + C00101 + C00003 <=> C00143 + C00014 + C00011 + C00004 + C00080
Comment
multienzyme system
multi-step reaction (see R03425+R04125+R03815)
Reaction class
RC00001  C00003_C00004
RC00022  C00101_C00143
RC02834  C00014_C00037
Enzyme
1.4.1.27
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01200  Carbon metabolism
Module
M00532  Photorespiration
M00621  Glycine cleavage system
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.27
     R01221  Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
Orthology
K00281  glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]
K00282  glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2]
K00283  glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2]
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00605  glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]
K02437  glycine cleavage system H protein
Other DBs
RHEA: 27761
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