KEGG   REACTION: R01933
Entry
R01933                      Reaction                               
Name
2-oxoadipate dehydrogenase complex
Definition
2-Oxoadipate + CoA + NAD+ <=> Glutaryl-CoA + CO2 + NADH + H+
Equation
C00322 + C00010 + C00003 <=> C00527 + C00011 + C00004 + C00080
Comment
2-oxoglutarate dehydrogenase complex (see R08549)
multienzyme system: ec 1.2.4.-, ec 2.3.1.61 and ec 1.8.1.4
multi-step reaction (see R01940+R02571+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00527
RC02833  C00322_C00527
Enzyme
1.2.1.-
Pathway
rn00380  Tryptophan metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.-
     R01933  2-Oxoadipate + CoA + NAD+ <=> Glutaryl-CoA + CO2 + NADH + H+
Orthology
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K15791  2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]
Other DBs
RHEA: 30798
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