KEGG   REACTION: R01960
Entry
R01960                      Reaction                               
Name
L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
Definition
L-Kynurenine + Oxygen + NADPH + H+ <=> 3-Hydroxy-L-kynurenine + NADP+ + H2O
Equation
C00328 + C00007 + C00005 + C00080 <=> C03227 + C00006 + C00001
Reaction class
RC00001  C00005_C00006
RC00046  C00328_C03227
Enzyme
1.14.13.9
Pathway
rn00380  Tryptophan metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.9
     R01960  L-Kynurenine + Oxygen + NADPH + H+ <=> 3-Hydroxy-L-kynurenine + NADP+ + H2O
Orthology
K00486  kynurenine 3-monooxygenase [EC:1.14.13.9]
Other DBs
RHEA: 20548
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