KEGG   REACTION: R02698
Entry
R02698                      Reaction                               
Name
4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)
Definition
4-Hydroxyphenylacetate + Oxygen + NADH + H+ <=> 3,4-Dihydroxyphenylacetate + NAD+ + H2O
Equation
C00642 + C00007 + C00004 + C00080 <=> C01161 + C00003 + C00001
Reaction class
RC00001  C00003_C00004
RC00046  C00642_C01161
Enzyme
1.14.14.9
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.9
     R02698  4-Hydroxyphenylacetate + Oxygen + NADH + H+ <=> 3,4-Dihydroxyphenylacetate + NAD+ + H2O
Orthology
K00483  4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K00484  flavin reductase (NADH) [EC:1.5.1.36]
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]
K16902  FAD reductase [NAD(P)H] [EC:1.5.1.45]
K23470  4-hydroxyphenylacetate 3-hydroxylase, reductase component [EC:1.5.1.36]
K23492  4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
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